Reduced risk of breast cancer upon intake of lutein-rich food supplements creates an interest to investigate the molecular mechanism underlying the growth inhibitory potential of lutein in MCF-7 and MDA-MB-231 cells. Lutein purified from Spinacia oleracea was identified by high-performance liquid chromatography and liquid chromatography-mass spectrometry. The cell viability was measured by watersoluble tetrazolium-1 assay. The intracellular reactive oxygen species level was examined by 2′,7′-dichlorofluorescein assay. The protein expression of the markers How to cite this article: Kavalappa YP, Gopal SS, Ponesakki G. Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell survival signals and induces apoptosis.

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