Dendritic cells (DCs) based cancer immunotherapy is largely dependent on adequate antigen delivery and efficient induction of DCs maturation to produce sufficient antigen presentation and ultimately lead to substantial activation of tumor‐specific CD8
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T cells. Carbon nanotubes (CNTs) have attracted great attention in biomedicine because of their unique physicochemical properties. In order to effectively deliver tumor antigens to DCs and trigger a strong anti‐tumor immune response, herein, a specific DCs target delivery system was assembled by using multi‐walled carbon nanotubes modified with mannose which can specifically bind to the mannose receptor on DCs membrane. Ovalbumin (OVA) as a model antigen, could be adsorbed on the surface of mannose modified multi‐walled carbon nanotubes (Man‐MWCNTs) with a large drug loading content. This nanotube‐antigen complex showed low cytotoxicity to DCs and was efficiently engulfed by DCs to induce DCs maturation and cytokine release in vitro, indicating that it could be a potent antigen‐adjuvant nanovector of efficient antigen delivery for therapeutic purpose.
With its wide bandgap, excellent electrical properties, and relative mature crystal growth technique, 4H-SiC is an attractive candidate material for fabricating high performance ultraviolet photodetectors, which have potential to work in harsh environments. In this work, a vertical type 4H-SiC Schottky-barrier photodiode is designed and fabricated. The photodiode exhibits very low dark current and high quantum efficiency in the entire temperature range from 25 to 200 °C. A high Schottky barrier height of over 1.58 eV and an ideality factor as low as 1.074 at room temperature are deduced for the semitransparent Ni/4H-SiC Schottky metal contact. The high-temperature reliability characteristics are evaluated by high-temperature storage at 200 °C and high-temperature spike annealing up to 550 °C.
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