This study investigates the preparation of ligustrazine hydrochloride carboxymethyl chitosan and collagen microspheres. This experiment investigates effects of the ratio of carboxymethyl chitosan and collagen blend, water to oil ratio, stirring speed, and other factors on the microsphere properties. The experiment had the following conditions: a 1:2 proportion of carboxymethyl chitosan and collagen, a 1:2 proportion of drugs and materials, a 5:1 proportion of oil phase and water phase, 0.5% of span80, a 600r/min stirring speed, 3 ml of a cross-linking agent, 3 h of crosslinking curing, 1.25 § 0.05 mm diameter LTH microcapsules, a 54.08% envelop rate, and a 14.16% carrier rate. The microspheres release rate reached 66% within 1 h, then steadily released within 5 h in vitro. The experimental results showed that the ligustrazine hydrochloride microsphere production process was stable and exhibited a good release effect compared with other ligustrazine hydrochloride tablets and pills.
Mercury (Hg) is a toxic heavy metal contaminant and has very harmful effects for human health. In this work, Hg-containing wastewater with Hg concentration of 6.36 ppb and 9.4 ppb were recovered with polyethylenimine (PEI) cross-linked graphene oxide (GO) layered membrane (c-GO-PEI) by pervaporation. The influence of ionic type, the concentration of Hg and the feed temperature were investigated. The c-GO-PEI exhibited not only high rejection for salts (> 99.97%), Hg (77.5–100%) and non-purgeable organic carbon (NPOC) (67.3–90.8%) but also high flux (30.30 kg·m−2·h−1) to treat with the wastewater. In addition, the flux could be largely recovered after simple washing, indicating the excellent antifouling property of the membrane.
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