As a departure from many previous case series, we found lung and breast metastases to be equally numerous in women and liver as the most common oral metastasis in men. Also, we identified a tendency for the patient to present with a previous history in certain malignancies, such as breast cancer, whereas in other malignancies, such as renal cell carcinoma, our data demonstrated a propensity to present in the oral cavity without history of a primary tumor.
Whole slide imaging (WSI) has impacted the practice of pathology in the arenas of education, clinical practice, and research. With digital slides, pathologists can circumvent the limitations of traditional glass. Presently, digital pathology is primarily utilized for second opinion consults, clinical conferences, and education at select academic medical centers, with its mainstream adoption on the rise. However, challenges of adoption for oral pathologists are unique given the highly specialized nature of their work. The hurdles include the high-cost instrumentation and regular maintenance, need for additional training, changes in traditional workflow, and integration with present software. Given these barriers, it remains unclear the extent to which slide scanning and virtual pathology should be adopted by oral pathologists at this conjuncture. This review seeks to shed light on the current state of WSI and analyzes the opportunities and challenges for oral pathology in the rapidly evolving field of digital pathology.
K E Y W O R D Sdigital pathology, image analysis, slide scanning, telepathology, whole slide imaging
Evaluation of bone pathology within the head and neck region, particularly the gnathic bonesis is complex, demonstrating unique pathologic processes. In part, this variation is due to odontogenesis and the embryological cells that may be involved, which can contribute to disease development and histologic variability. As with any boney pathosis, the key is to have clinical correlation, particularly with radiographic imaging prior to establishing a definitive diagnosis. This review will cover those entities that have a predilection for the pediatric population, and while it is not all inclusive, it should serve as a foundation for the pathologist who is evaluating bony lesions involving the craniofacial skeleton.
Soft soils are characterized by high sensitivity, low strength, and susceptibility to seismic subsidence. In this study, nonlinear dynamic finite element analysis was performed by OpenSees numerical simulation method to evaluate seismic subsidence response of soft soil site to input ground motions. Higher peak acceleration of ground motion enhanced degree of uneven seismic subsidence, depth of seismic depression, and damage to horizontal surface. Frequency characteristics of a ground motion are another factor influencing seismic subsidence of soft soil. Similar predominant frequency of a ground motion to natural frequency of soil site, high number of low frequency contents, and high amplitude of a ground motion promoted a more severe seismic subsidence of soft soil. The findings of this study expand current understanding on seismic subsidence of soft soil.
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