Analytic survey of 57 cases of oral metastases

Abstract

As a departure from many previous case series, we found lung and breast metastases to be equally numerous in women and liver as the most common oral metastasis in men. Also, we identified a tendency for the patient to present with a previous history in certain malignancies, such as breast cancer, whereas in other malignancies, such as renal cell carcinoma, our data demonstrated a propensity to present in the oral cavity without history of a primary tumor.

Metastasis of Renal Cell Carcinoma Causing Significant Facial Asymmetry

“…Metastases to the oral cavity or head and neck region are extremely rare conditions [7, 9]. Metastatic tumors account for less than 1% of all oral malignancies [7, 10]. Such metastases can affect men and women equally and at any age [11].…”

“…According to Hirshberg et al [4], the kidney is the third most common primary site for oral metastases, although there is underreporting [8]. The incidence of oral metastases and their origins may vary according to the study population [4, 7, 11].…”

“…The clinical and radiological aspects of metastatic tumors are varied, making diagnosis and therapeutic management challenging [6], so it is highly relevant to investigate the patient's medical history. The lesions may be asymptomatic or painful and may cause paresthesia, tooth mobility, regional lymphadenopathy, local swelling, exophytic growth, modification of the normal aspects of the oral mucosa, and still pathologic fracture in osseous lesions [7].…”

“…Histopathological findings are essential and generally reflect the pattern of primary tumors [8]. Due to the rarity of these metastatic tumors in the maxillofacial region and the challenging diagnosis, the immunohistochemical expression is an auxiliary diagnostic tool [7, 8].…”

Oral and Maxillary Metastases: Retrospective Clinical Analysis of 21 Cases

“…A literature review of recent similar single/double institution case-series as ours is performed, with more than 15 cases and a 10-year period minimum (Table III) 5,[7][8][9][10][11][12][13][14][15][16][17][18][19] . Inclusion and exclusion criteria are very heterogeneous.…”