Apolipoproteins (APOs), the primary protein moiety of lipoproteins, are known for their crucial role in lipid traffic and metabolism. Despite extensive exploration of APOs in cardiovascular diseases, their roles in cancers did not attract enough attention. Recently, research focusing on the roles of APOs in cancers has flourished. Multiple studies demonstrate the interaction of APOs with classical pathways of tumorigenesis. Besides, the dysregulation of APOs may indicate cancer occurrence and progression, thus serving as potential biomarkers for cancer patients. Herein, we summarize the mechanisms of APOs involved in the development of various cancers, their applications as cancer biomarkers and their genetic polymorphism associated with cancer risk. Additionally, we also discuss the potential anti-cancer therapies by virtue of APOs. The comprehensive review of APOs in cancers may advance the understanding of the roles of APOs in cancers and their potential mechanisms. We hope that it will provide novel clues and new therapeutic strategies for cancers.
Steel plate shear walls (SPSWs) offer good energy dissipation capability when subjected to seismic forces as a robust lateral load resisting structure. This research investigated the cyclic behaviors of innovative infill web-strips (IWS-SPSW) and conventional unstiffened steel plate shear (USPSW) experimentally and numerically. As a result, two specimens of a 1:3 scale three-story single-bay IWS-SPSW and USPSW were fabricated and tested under cyclic lateral loading. Rigid moment-resistant connections were used for the steel plate shear wall beam-column connection. The steel shear walls with infill web strips showed high ductility and less shear load-bearing than the USPSW. The hysteresis results showed that the IWS-SPSW had high energy dissipation with no severe beam-columns damages. On the other hand, the USPSW displayed severe post-buckling, infill panel cracks, and first-floor column damages. Moreover, the IWS-SPSW shear strength did not fall in the test specimen beyond 2.5% average story drift, where the structure exhibited great seismic behavior. FE models were created and validated with experimental data. It has been proven that the infill web-strips can affect an SPSW system’s high performance and overall energy dissipation. From a parametric study, the material features of the infill web-strips, such as steel strength and thickness, can enhance the system’s impact even more.
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