Two new triterpenoid saponins (1-2), with eleven known compounds (3-13) were obtained from ethyl acetate extracts of Anemone tomentosa (Maxim.) Pei by bioactivity-guided isolation. Their structures were elucidated by chemical and spectral analysis, including 1D, 2D NMR data and HRESIMS. The cytotoxic activity of all isolated saponins was evaluated on MDA-MB-231 and PC-3 cell lines.Compounds 5 and 7 showed significant cytotoxicity against with MDA-MB-231 cell and PC-3 cell with IC 50 values of 3. 73-4.21 μM and 3.53-5.37 μM, respectively.
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