Stimuli‐triggered in‐situ morphological transformation of peptide nanomaterials may enhance the on‐site accumulation and retention of the imaging agent cargos in the stimuli‐rich regions, thus enabling precise, sensitive, and prolonged imaging of diseases. Moreover, this strategy permits the co‐delivery of contrast agents and drugs with the smart “turn‐on” ability, allowing for efficient disease theranostics. In light of the significance of this strategy in designing smart biomedical peptide materials, which remains scarcely reviewed in recent years, we herein provide this review. We summarize the bioimaging applications (i. e., fluorescence imaging, magnetic resonance imaging, and photoacoustic imaging) of these smart morphological transformation‐based peptide materials, and highlight the remarkable breakthroughs. Besides, challenges to be addressed in this field are discussed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.