Morphological Transformation of Self‐Assembled Peptide Nanostructures for Bioimaging Applications

Abstract

Stimuli‐triggered in‐situ morphological transformation of peptide nanomaterials may enhance the on‐site accumulation and retention of the imaging agent cargos in the stimuli‐rich regions, thus enabling precise, sensitive, and prolonged imaging of diseases. Moreover, this strategy permits the co‐delivery of contrast agents and drugs with the smart “turn‐on” ability, allowing for efficient disease theranostics. In light of the significance of this strategy in designing smart biomedical peptide materials, which remains scarcely reviewed in recent years, we herein provide this review. We summarize the bioimaging applications (i. e., fluorescence imaging, magnetic resonance imaging, and photoacoustic imaging) of these smart morphological transformation‐based peptide materials, and highlight the remarkable breakthroughs. Besides, challenges to be addressed in this field are discussed.

Stimuli-instructed sequential morphological transformations for molecular imaging

“…In addition, physical (e.g., co-assembly) or chemical (e.g., chemical integration) modifications of peptide molecules are relatively easy to carry out, leading to controllable imaging properties. 27 Considering that earlier reviews have summarized stimuli-triggered morphological transformation of peptide-based probes, [28][29][30] in this review, we focus mainly on dual stimuli-instructed cascade self-assembly and disassembly or tandem selfassembly of peptide-based probes for molecular imaging (Fig. 1), which enables precise and sensitive imaging or efficient theranostics and provides multiple types of information about diseases.…”