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A method for measuring the velocity of erythrocytes in the hepatic sinusoids of the rat is described. The liver is immobilized by the use of a diaphragmatic screen and a cover glass over the anterior edge of the liver which adheres by surface tension. The liver is transilluminated by light transmitted through a flexible optical fibre guide. Erythrocyte velocity is measured by continuous photometry of the magnified microscopic image of a hepatic sinusoid; two adjacent phototransistors generate signals as the images of red cells pass them, and the erythrocyte velocity is determined from the time difference in the two signals. Intraportal injection of adrenaline caused a significant increase in the velocity.