Summary:In this study, clinical findings with macroscopic and microscopic pathologic changes of the tissues and organs after necropsy examination at the 1 st , 2 nd , 3 rd , 5 th and 7 th days following intraperitoneally injection of Nile tilapia (Oreochromis niloticus) with Aeromonas hydrophila was aimed to be observed. Clinically; weakness, anorexia, swimming closer to surface, darkness in color with hyperemia and lysis of the fins were observed. In the macroscopic examination the liver was seen to be yellowish brown and crispy with haemorrhagic and greyish white foci on the surface. The gall bladder was tightly full with emerald green bile. The kidney and hearth had haemorrhagic foci whilst intestine lumina observed to be filled with yellow coloured mucoid liquid. The degenerative changes, cytoplasmic fat vacuols and lymphocyte infiltration in lever with focal necrosis of hepatocytes and pancreatic cells were observed histologically. The skin, spleen, gill and eyes did not reveal any significant symptoms. The haemorrhagies and intensive lymphocyte infiltrations in liver, kidney and hearth both in macroscopic and microscopic levels revealed a visceral haemorrhagic septicemia. In this sense; clinical, macroscopic and microscopic findings observed during the present study complied with the Aeromonas hydrophila infections recorded in the other fresh water fishes.
This report describes the ultrastructural alterations observed in the bronchial mucosa of a 29-year old male patient suffering from chronic upper and lower respiratory tract infections since his childhood and operated due to bronchiectasis and sinusitis. Electron microscopic evaluation of the bronchial biopsy specimens revealed ciliated cells appeared to be replaced by columnar cells lacking cilia and basal bodies, and bearing on their surface ciliumlike projections without any internal axonemal structure. These ultrastructural features are consistent with complete ciliary aplasia which is a rare form of primary ciliary dyskinesia.
ÖZETBu yazıda çocukluğunda bronşektazi ve sinüzit nedeniyle ameliyat olan, kronik üst ve alt solunum yollarında kronik infeksiyonu olan 29 yaşındaki erkek hastanın bronş mukozasının mikroskopik incelemesinde anormallik saptanmıştır. Bronş biyopsisi örneklerinin elekron mikroskopik incelemesinde silialı hücrelerin olması gereken bölgelerde kübik hücrelerin olduğu, siliaların ve bazal cisimciklerin yok olduğu, içinde internal aksonal yapı olmayan siliaya benzer yapıların olduğu izlendi. Bu mikroskopik bulgular primer siliyer diskinezinin nadir bir formu olan komplet silier aplazi varlığını göstermektedir.
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