Previous results showed that putative Rho-GEF Gef2 regulates division-site positioning during early cytokinesis in fission yeast. Here Nod1 is identified as a binding partner of Gef2. The two proteins form a complex to regulate division-site positioning and contractile-ring maintenance. In addition, Gef2 binds to GTPases Rho1, Rho4, and Rho5 in vitro.
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