Face de-identification has become increasingly important as the image sources are explosively growing and easily accessible. The advance of new face recognition techniques also arises peoples concern regarding the privacy leakage. The mainstream pipelines of face de-identification are mostly based on the k-same framework, which bears critiques of low effectiveness and poor visual quality. In this paper, we propose a new framework called Privacy-Protective-GAN (PP-GAN) that adapts GAN with novel verificator and regulator modules specially designed for the face de-identification problem to ensure generating deidentified output with retained structure similarity according to a single input. We evaluate the proposed approach in terms of privacy protection, utility preservation, and structure similarity. Our approach not only outperforms existing face de-identification techniques but also provides a practical framework of adapting GAN with priors of domain knowledge.

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Long non-coding RNAs (lncRNAs) are a class of RNA molecules with more than 200 nucleotides. A growing amount of evidence reveals that subcellular localization of lncRNAs can provide valuable insights into their biological functions. Existing computational methods for predicting lncRNA subcellular localization use k-mer features to encode lncRNA sequences. However, the sequence order information is lost by using only k-mer features. We proposed a deep learning framework, DeepLncLoc, to predict lncRNA subcellular localization. In DeepLncLoc, we introduced a new subsequence embedding method that keeps the order information of lncRNA sequences. The subsequence embedding method first divides a sequence into some consecutive subsequences and then extracts the patterns of each subsequence, last combines these patterns to obtain a complete representation of the lncRNA sequence. After that, a text convolutional neural network is employed to learn high-level features and perform the prediction task. Compared with traditional machine learning models, popular representation methods and existing predictors, DeepLncLoc achieved better performance, which shows that DeepLncLoc could effectively predict lncRNA subcellular localization. Our study not only presented a novel computational model for predicting lncRNA subcellular localization but also introduced a new subsequence embedding method which is expected to be applied in other sequence-based prediction tasks. The DeepLncLoc web server is freely accessible at http://bioinformatics.csu.edu.cn/DeepLncLoc/, and source code and datasets can be downloaded from https://github.com/CSUBioGroup/DeepLncLoc.

Motivation Exploring drug-protein interactions (DPIs) provides a rapid and precise approach to assist in laboratory experiments for discovering new drugs. Network-based methods usually utilize a drug-protein association network and predict DPIs by the information of its associated proteins or drugs, called “guilt-by-association” principle. However, the “guilt-by-association” principle is not always true because sometimes similar proteins cannot interact with similar drugs. Recently, learning-based methods learn molecule properties underlying DPIs by utilizing existing databases of characterized interactions but neglect the network-level information. Results We propose a novel method, namely BridgeDPI. We devise a class of virtual nodes to bridge the gap between drugs and proteins and construct a learnable drug-protein association network. The network is optimized based on the supervised signals from the downstream task — the DPI prediction. Through information passing on this drug-protein association network, a graph neural network can capture the network-level information among diverse drugs and proteins. By combining the network-level information and the learning-based method, BridgeDPI achieves significant improvement in three real-world DPI datasets. Moreover, the case study further verifies the effectiveness and reliability of BridgeDPI. Availability The source code of BridgeDPI can be accessed at https://github.com/SenseTime-Knowledge-Mining/BridgeDPI.

Motivation The identification of compound-protein interactions (CPIs) is an essential step in the process of drug discovery. The experimental determination of CPIs is known for a large amount of funds and time it consumes. Computational model has therefore become a promising and efficient alternative for predicting novel interactions between compounds and proteins on a large scale. Most supervised machine learning prediction models are approached as a binary classification problem, which aim to predict whether there is an interaction between the compound and the protein or not. However, compound-protein interaction is not a simple binary on-off relationship, but a continuous value reflects how tightly the compound binds to a particular target protein, also called binding affinity. Results In this study, we propose an end-to-end neural network model, called BACPI, to predict compound-protein interaction and binding affinity. We employ graph attention network (GAT) and convolutional neural network (CNN) to learn the representations of compounds and proteins, and develop a bi-directional attention neural network model to integrate the representations. To evaluate the performance of BACPI, we use three CPI datasets and four binding affinity datasets in our experiments. The results show that, when predicting CPIs, BACPI significantly outperforms other available machine learning methods on both balanced and unbalanced datasets. This suggests that the end-to-end neural network model that predicts CPIs directly from low level representations is more robust than traditional machine learning-based methods. And when predicting binding affinities, BACPI achieves higher performance on large datasets compared to other state-of-the-art deep learning methods. This comparison result suggests that the proposed method with bi-directional attention neural network can capture the important regions of compounds and proteins for binding affinity prediction. Availability and implementation Data and source codes are available at https://github.com/CSUBioGroup/BACPI Supplementary information Supplementary data are available at Bioinformatics online.

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