Instance-level human parsing towards real-world human analysis scenarios is still under-explored due to the absence of sufficient data resources and technical difficulty in parsing multiple instances in a single pass. Several related works all follow the "parsing-by-detection" pipeline that heavily relies on separately trained detection models to localize instances and then performs human parsing for each instance sequentially. Nonetheless, two discrepant optimization targets of detection and parsing lead to suboptimal representation learning and error accumulation for final results. In this work, we make the first attempt to explore a detection-free Part Grouping Network (PGN) for efficiently parsing multiple people in an image in a single pass. Our PGN reformulates instance-level human parsing as two twinned sub-tasks that can be jointly learned and mutually refined via a unified network: 1) semantic part segmentation for assigning each pixel as a human part (e.g., face, arms); 2) instance-aware edge detection to group semantic parts into distinct person instances. Thus the shared intermediate representation would be endowed with capabilities in both characterizing fine-grained parts and inferring instance belongings of each part. Finally, a simple instance partition process is employed to get final results during inference. We conducted experiments on PASCAL-Person-Part dataset and our PGN outperforms all state-of-the-art methods. Furthermore, we show its superiority on a newly collected multi-person parsing dataset (CIHP) including 38,280 diverse images, which is the largest dataset so far and can facilitate more advanced human analysis. The CIHP benchmark and our source code are available at http://sysu-hcp.net/lip/.

Rapid, accurate and high-throughput sizing and quantification of particulate matter (PM) in air is crucial for monitoring and improving air quality. In fact, particles in air with a diameter of ≤2.5 μm have been classified as carcinogenic by the World Health Organization. Here we present a field-portable cost-effective platform for high-throughput quantification of particulate matter using computational lens-free microscopy and machine-learning. This platform, termed c-Air, is also integrated with a smartphone application for device control and display of results. This mobile device rapidly screens 6.5 L of air in 30 s and generates microscopic images of the aerosols in air. It provides statistics of the particle size and density distribution with a sizing accuracy of ~93%. We tested this mobile platform by measuring the air quality at different indoor and outdoor environments and measurement times, and compared our results to those of an Environmental Protection Agency–approved device based on beta-attenuation monitoring, which showed strong correlation to c-Air measurements. Furthermore, we used c-Air to map the air quality around Los Angeles International Airport (LAX) over 24 h to confirm that the impact of LAX on increased PM concentration was present even at >7 km away from the airport, especially along the direction of landing flights. With its machine-learning-based computational microscopy interface, c-Air can be adaptively tailored to detect specific particles in air, for example, various types of pollen and mold and provide a cost-effective mobile solution for highly accurate and distributed sensing of air quality.

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In the past decades, Moore’s law drives the semiconductor industry to continuously shrink the critical size of transistors down to 7 nm. As transistors further downscaling to smaller sizes, the law reaches its limitation, and the increase of transistors density on the chip decelerates. Up to now, extreme ultraviolet lithography has been used in some key steps, and it is facing alignment precision and high costs for high-volume manufacturing. Meanwhile, the introduction of new materials and 3D complex structures brings serious challenges for top-down methods. Thus, bottom-up schemes are believed to be necessary methods combined with the top-down processes. In this article, atomic level deposition methods are reviewed and categorized to extend Moore’s law and beyond. Firstly, the deposition brings lateral angstrom resolution to the vertical direction as well as top-down etching, such as double patterning, transfer of nanowires, deposition of nanotubes, and so on. Secondly, various template-assisted selective deposition methods including dielectric templates, inhibitors and correction steps have been utilized for the alignment of 3D complex structures. Higher resolution can be achieved by inherently selective deposition, and the underlying selective mechanism is discussed. Finally, the requirements for higher precision and efficiency manufacturing are also discussed, including the equipment, integration processes, scale-up issues, etc. The article reviews low dimensional manufacturing and integration of 3D complex structures for the extension of Moore’s law in semiconductor fields, and emerging fields including but not limited to energy, catalysis, sensor and biomedicals.

Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial.

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