The
current reported photosensitizers generally show a decreased
reactive oxygen species (ROS) generation property under hypoxia conditions,
which is the main reason for the clinical failure of photodynamic
therapy (PDT) in treatment of solid tumors. Herein, for the first
time, hypoxia-induced photogenic radicals by eosin Y (Eos) were reported
for efficient phototherapy of hypoxic tumors. More importantly, Eos
shows a higher ROS and radical production efficiency under hypoxia
conditions than under normoxia conditions. The photogenic radicals
were captured by electron paramagnetic resonance and further verified
by ROS and radical probe. Introducing CoCl2 as a hypoxia
inducer, the photoinduced therapy of the hypoxia cancer cell model
and tumor-bearing mice indicated that bovine serum albumin–Eos
in hypoxic tumor sites can produce even higher tumor toxicity, thereby
crossing the clinical obstacles of hypoxic tumor therapy. This non-oxygen-dependent
PDT may open up an avenue for fighting with hypoxia.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.