This paper analyses topic segmentation based on the LDA (Latent Dirichlet Allocation) model, and performs the topic segmentation and topic evolution of stem cell research literatures in PubMed from 2001 to 2012 by combining the HMM (Hidden Markov Model) and co-occurrence theory. Stem cell research topics were obtained with LDA and expert judgements made on these topics to test the feasibility of the model classification. Further, the correlation between topics was analysed. HMM was used to predict the trend evolution of topics over various years, and a time series map was used to visualize the evolutional relationships among the stem cell topics.

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Early detection and intervention of cerebral palsy can promote neural remodeling in the process of brain development, thus reducing the negative effects of cerebral palsy. In this paper, we proposed a novel method for early prediction of infant cerebral palsy based on General Movements Assessment (GMA) theory with RGB-D videos. Firstly, we explored the human pose recognition in supine position based on RGB-D videos. Then we further apply it to auto-GMA. Specifically, we employ current pose estimation method on RGB images to achieve the infant full body 2D key points. By combining the depth information, the 3D movement of infant in supine position can be obtained. Then the infant's movement complexity index is achieved by extracting the infant's whole-body movement characteristic. In order to verify the effectiveness of the method, we did some experiments on a public dataset consisting 12 real recorded infants' movement RGB-D videos, with 4 of the samples were diagnosed as abnormal infants by a GMA expert. We use expert GMA ratings of these recorded movements as the gold standard. Our method achieved state-of-the-art with sensitivity of 100%, specificity of 87.5%, and accuracy of 91.7%. The results show that the method has great potential in assisting doctors in diagnose infant cerebral palsy.

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Many of current human pose estimation methods based on depth images require training stage. However, the training stage costs huge work on making samples. And many methods for human pose occlusion condition cannot work well. In this study, a novel approach to estimate human pose with a depth image called model-based recursive matching (MRM) is introduced. A human skeleton model with customised parameters is created based on T-pose to fit different body types. The authors use depth image and 3D point cloud corresponding to input. In contrast to previous work, the proposed method avoids training step and can give an accurate estimation in the case of the human occlusion condition. They demonstrate the method by comparing to the method Kinect offered by using random forest on 20 human poses. And the ground truth of coordinates of pose joint is made by the motion capture system. The result shows that the proposed method not only works well on the general human pose but also can deal with human occlusion better. And the authors' method can be also applied to the disabled people and other creatures.

Motivation Polypharmacy is the combined use of drugs for the treatment of diseases. However, it often shows a high risk of side effects. Due to unnecessary interactions of combined drugs, the side effects of polypharmacy increase the risk of disease and even lead to death. Thus, obtaining abundant and comprehensive information on the side effects of polypharmacy is a vital task in the healthcare industry. Early traditional methods employed machine learning techniques to predict side effects. However, they often make costly efforts to extract features of drugs for prediction. Later, several methods based on knowledge graphs are proposed. They are reported to outperform traditional methods. However, they still show limited performance by failing to model complex relations of side effects among drugs. Results To resolve the above problems, we propose a novel model by further incorporating complex relations of side effects into knowledge graph embeddings. Our model can translate and transmit multidirectional semantics with fewer parameters, leading to better scalability in large-scale knowledge graphs. Experimental evaluation shows that our model outperforms state-of-the-art models in terms of the average area under the ROC and precision-recall curves. Availability Code and data are available at: https://github.com/galaxysunwen/MSTE-master