Angiogenesis is an indispensable mechanism in development and in many pathologies, including cancer, synovitis and aberrant wound healing. Many angiogenic stimulators and inhibitors have been investigated, and some have progressed to the clinic. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a group of multifunctional proteinases. ADAMTS-1 and ADAMTS-8 have been reported to be anti-angiogenic. Here, we provide evidence that ADAMTS-4, like ADAMTS-1, is expressed by endothelial cells and binds to vascular endothelial groth factor (VEGF). Moreover, ADAMTS-4 inhibited human dermal microvascular endothelial cells (HuDMEC) VEGF-stimulated VEGF receptor (R) R2 phosphorylation, differentiation and migration, suggesting that ADAMTS-4 may be a novel anti-angiogenic molecule.

This study investigates differences in request e-mails written in English by Chinese English learners and native American English speakers The results show that while Chinese English learners treat e-mail communications like either formal letters or telephone conversations, native American English speakers regard e-mail communications as closer to written memos It was also found that although the native American English speakers structure their e-mail request messages in a rather direct sequence, the linguistic forms they employ to express their requests are more indirect In contrast, the Chinese English learners structure their request messages in an indirect sequence, but the linguistic forms they use to realize their requests are more direct Given this contrast, it is not surprising that some of the request samples written by Chinese English learners were judged as very impolite by the native English speaking evaluators in this study The findings of this study thus demonstrate the importance of studying requests within the overall discourse in which they occur. Studying only the linguistic forms used in phrasing the request itself, as in the studies conducted by Blum-Kulka et al (1989), cannot provide us with a full picture of the cultural differences inherent in making requests

This study performed beat-to-beat and spectral analyses of 20-minute skin-surface laser-Doppler-flowmetry (LDF) and radial blood-pressure-waveform (BPW) signals in order to compare the blood-flow perfusion condition and regulatory mechanisms between essential-hypertension (EHT) patients and aged-matched control subjects. Beat-to-beat LDF analyses yielded the pulse width (PW), AC-to-DC ratio (AD), and their corresponding variability indices (coefficients of variation [CVs]). The relative energy contributions (RECs) of five characteristic frequency peaks (defined as FR1–FR5) were also calculated. Spectral BPW analysis obtained the amplitude proportion (C n ) and phase angle (P n ) of each harmonic component n. PW, AD, AD_CV, and REC of FR2 were significantly smaller in the EHT group than in the control group. Regarding BPW indices, C 1, C 2, C 4, and C 5 were significantly larger and P 2–P 8 were significantly smaller in EHT patients than in controls. The present results indicate that BPW and LDF indices can be used to evaluate the blood-flow perfusion efficiency and microcirculatory regulatory activities in EHT. Sex differences were found, with the effects being more prominent in female patients. These findings may be partly attributable to impairment of endothelial and neural regulatory functions. The present findings might aid the development of new noninvasive methods for reducing the risk of EHT-induced damage.