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High preoperative NLR was associated with increased tumor size and high ATA risk of recurrence in patients with differentiated thyroid cancer.

Postseismic displacements of as much as 14 cm were recorded by GPS measurements in the 3 months following the MW 7.6 1999 Chi‐Chi, Taiwan earthquake. Data from 35 continuous and 90 campaign‐surveyed stations, which show continued east over west thrusting, are analyzed to estimate the postseismic slip distribution and fault geometry. Assuming the shallow fault dips 24° E, as determined by numerous studies of the mainshock, we invert for the deeper fault structure. Our results show that the fault dip shallows with depth below the hypocenter, merging into a nearly horizontal decollement at a depth of 8–12 km. The afterslip distribution shows a maximum slip of 25 cm in the hypocentral region at 7–12 km depth as well as significant slip on the lower decollement. Afterslip is notably absent in the region of maximum coseismic slip, consistent with the afterslip being driven by the mainshock stress change.

Local anesthetics are frequently used in fine-needle aspiration of thyroid lesions and locoregional control of persistent or recurrent thyroid cancer. Recent evidence suggests that local anesthetics have a broad spectrum of effects including inhibition of cell proliferation and induction of apoptosis in neuronal and other types of cells. In this study, we demonstrated that treatment with lidocaine and bupivacaine resulted in decreased cell viability and colony formation of both 8505C and K1 cells in a dose-dependent manner. Lidocaine and bupivacaine induced apoptosis, and necrosis in high concentrations, as determined by flow cytometry. Lidocaine and bupivacaine caused disruption of mitochondrial membrane potential and release of cytochrome c, accompanied by activation of caspase 3 and 7, PARP cleavage, and induction of a higher ratio of Bax/Bcl-2. Based on microarray and pathway analysis, apoptosis is the prominent transcriptional change common to lidocaine and bupivacaine treatment. Furthermore, lidocaine and bupivacaine attenuated extracellular signal-regulated kinase 1/2 (ERK1/2) activity and induced activation of p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase. Pharmacological inhibitors of MAPK/ERK kinase and p38 MAPK suppressed caspase 3 activation and PARP cleavage. Taken together, our results for the first time demonstrate the cytotoxic effects of local anesthetics on thyroid cancer cells and implicate the MAPK pathways as an important mechanism. Our findings have potential clinical relevance in that the use of local anesthetics may confer previously unrecognized benefits in the management of patients with thyroid cancer.

, the Mw 7.6 Chi-Chi earthquake ruptured a segment of the Chelungpu Fault, a frontal thrust fault of the Western Foothills of Taiwan. The stress perturbation induced by the rupture triggered a transient deformation across the island, which was well recorded by a wide network of continuously operating GPS stations. The analysis of more than ten years of these data reveals a heterogeneous pattern of postseismic displacements, with relaxation times varying by a factor of more than ten, and large cumulative displacements at great distances, in particular along the Longitudinal Valley in eastern Taiwan, where relaxation times are also longer. We show that while afterslip is the dominant relaxation process in the epicentral area, viscoelastic relaxation is needed to explain the pattern and time evolution of displacements at the larger scale. We model the spatiotemporal behavior of the transient deformation as the result of afterslip on the décollement that extends downdip of the Chelungpu thrust, and viscoelastic flow in the lower crust and in the mid-crust below the Central Range. We construct a model of deformation driven by coseismic stress change where afterslip and viscoelastic flow are fully coupled. The model is compatible with the shorter relaxation times observed in the near field, which are due to continued fault slip, and the longer characteristic relaxation times and the reversed polarity of vertical displacements observed east of the Central Range. Our preferred model shows a viscosity of 0.5-1 Â 1019 Pa s at lower-crustal depths and 5 Â 10 17 Pa s in the mid-crust below the Central Range, between 10 and 30 km depth. The low-viscosity zone at mid-crustal depth below the Central Range coincides with a region of low seismicity where rapid advection of heat due to surface erosion coupled with underplating maintain high temperatures, estimated to be between 300 C and 600 C from the modeling of thermo-chronology and surface heat flow data.

These results implicated YAP1 R331W as an allele predisposed for lung adenocarcinoma with high familial penetrance. Low-dose computed tomography scans may be recommended to this subpopulation, which is at high risk for lung cancer, for personalized prevention and health management.

Background and Aims. High levels of parathyroid hormone (PTH) appear to be associated with an increased mortality. Previous studies concerning the relationship of inflammatory markers with hyperparathyroidism have yielded inconsistent results. This study investigated whether serum PTH concentrations were independently associated with several inflammatory markers among the US adults. Materials and Methods. Using data from the National Health and Nutrition Examination Survey, we examined the relation between serum PTH and C-reactive protein (CRP), red cell distribution width (RDW), and platelet-to-lymphocyte ratio (PLR) levels with weighted linear regression. Additionally, we examined the relation with increased modified Glasgow Prognostic Score (mGPS) by using weighted logistic regression. Results. CRP, RDW, and PLR values increased with increasing serum PTH concentration. After extensively adjusting for covariates, CRP and RDW increased linearly and across PTH categories (all P < 0.001), while PLR marginally increased (P = 0.190 and P = 0.095 using PTH as a categorical and continuous variable, resp.). The odds ratio of increased mGPS was 1.11 and 1.31 across PTH categories and with increasing PTH levels continuously. Conclusion. These nationally representative data indicate that serum PTH levels are independently associated with several inflammatory markers in the US population. The casual relationship between PTH levels and inflammation remains to be elucidated.

The strength of the lithosphere controls tectonic evolution and seismic cycles, but how rocks deform under stress in their natural settings is usually unclear. We constrain the rheological properties beneath the Taiwan orogenic belt using the stress perturbation following the 1999 Chi-Chi earthquake and fourteen-year postseismic geodetic observations. The evolution of stress and strain rate in the lower crust is best explained by a power-law Burgers rheology with rapid increases in effective viscosities from ~1017to ~1019Pa s within a year. The short-term modulation of the lower-crustal strength during the seismic cycle may alter the energy budget of mountain building. Incorporating the laboratory data and associated uncertainties, inferred thermal gradients suggest an eastward increase from 19.5±2.5°C/km in the Coastal Plain to 32±3°C/km in the Central Range. Geodetic observations may bridge the gap between laboratory and lithospheric scales to investigate crustal rheology and tectonic evolution.