Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies

Sung, Yun‐Chieh; Jin, Pei-Ru; Chu, Li; Hsu, Fu Fei; Wang, Mei Ren; Chang, Chih Chun; Chiou, Show Jen; Qiu, Jian Tai; Gao, Dong; Lin, Chu Chi; Chen, Yu Sing; Hsu, Yi Chiung; Wang, Jane; Wang, Fu Nien; Yu, Peng; Chiang, Ann‐Shyn; Wu, Anthony Yan Tang; Ko, John Jun Sheng; Lai, Charles P.; Lu, Tsai‐Te; Chen, Yunching

doi:10.1038/s41565-019-0570-3

Cited by 311 publications

(240 citation statements)

References 44 publications

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“…Biodegradable polymers have been at the forefront of research for biomedical applications in the last 50 years. The advancements have been seen in the areas of using biodegradable polymers as delivery vehicles for controlled drug release [76][77][78] and development of therapeutic devices [77][78][79], including implants and three-dimensional scaffolds for tissue engineering [80][81][82][83].…”

Section: Medical Applicationsmentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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The success of oil-based plastics and the continued growth of production and utilisation can be attributed to their cost, durability, strength to weight ratio, and eight contributions to the ease of everyday life. However, their mainly single use, durability and recalcitrant nature have led to a substantial increase of plastics as a fraction of municipal solid waste. The need to substitute single use products that are not easy to collect has inspired a lot of research towards finding sustainable replacements for oil-based plastics. In addition, specific physicochemical, biological, and degradation properties of biodegradable polymers have made them attractive materials for biomedical applications. This review summarises the advances in drug delivery systems, specifically design of nanoparticles based on the biodegradable polymers. We also discuss the research performed in the area of biophotonics and challenges and opportunities brought by the design and application of biodegradable polymers in tissue engineering. We then discuss state-of-the-art research in the design and application of biodegradable polymers in packaging and emphasise the advances in smart packaging development. Finally, we provide an overview of the biodegradation of these polymers and composites in managed and unmanaged environments.

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Section: Medical Applicationsmentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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“…Nevertheless, long-term toxic effect study is needed in the further research. There has been reported that RT, mild heating as well as nitric oxide make tumor more responsive to immunotherapy [57,58,11].We next studied the anticancer immune response induced by our enhanced RT therapy. OVA is a T-cell-dependent antigen commonly used as a model protein for studying antigen-specific immune responses in mice.…”

Section: Resultsmentioning

confidence: 99%

“…In addition to many heavy metals (e.g., gold, platinum, silver) that could enlargement radiation effects, nitric oxide (NO) is known a very effective radiosensitizer of hypoxic tumor as well [8][9][10][11][12][13]. It has previously been shown that DNA damage induced by NO during radiation is remarkably enhanced [2,9,[14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy

et al. 2020

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HIGHLIGHTS • Ag 2 S NO delivery platforms maximize radiotherapy effects remarkably to inhibit the tumor growth. • Immunosuppressive tumor microenvironment was improved by Ag 2 S NO delivery system, significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy. ABSTRACT Radiotherapy (RT) is a widely used way for cancer treatment. However, the efficiency of RT may come with various challenges such as low specificity, limitation by resistance, high dose and so on. Nitric oxide (NO) is known a very effective radiosensitizer of hypoxic tumor. However, NO cannot circulate in body with high concentration. Herein, an NIR light-responsive NO delivery system is developed for controlled and precisely release of NO to hypoxic tumors during radiotherapy. Tert-Butyl nitrite, which is an efficient NO source, is coupled to Ag 2 S quantum dots (QDs). NO could be generated and released from the Ag 2 S QDs effectively under the NIR irradiation due to the thermal effect. In addition, Ag is also a type of heavy metal that can benefit the RT therapy. We demonstrate that Ag 2 S NO delivery platforms remarkably maximize radiotherapy effects to inhibit tumor growth in CT26 tumor model. Furthermore, immunosuppressive tumor microenvironment is improved by our NO delivery system, significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy. 100% survival rate is achieved by the radio-immune combined therapy strategy based on the Ag 2 S NO delivery platforms. Our results suggest the promise of Ag 2 S NO delivery platforms for multifunctional cancer radioimmunotherapy.

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“…[ 7 ] Analysis of the relevant literature shows that NO also participates in the regulation of various physiological processes, including vascular relaxation, immune regulation, neurotransmission, bone metabolism, among many others. [ 8–13 ]…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Engineering of a Scavenger‐Free Nitric Oxide‐Generating/Delivering System to Enhance Radiation Therapy

Lin

Chen

Nguyen

et al. 2020

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Nitric oxide (NO) is a potent tumor‐cell radiosensitizer but it can be readily scavenged by hemoglobin (Hb) in vivo. A biomimetic incubator that can generate and deliver NO in a scavenger (Hb)‐free environment to enhance its radiosensitizing effect to maximize its efficacy in radiotherapy is proposed. This NO incubator comprises a poly(lactic‐co‐glycolic acid) (PLGA) hollow microsphere (HM) that contains an NO donor (NONOate) and a surfactant molecule (sodium caprate, SC) in its aqueous core. In acidic tumorous environments, the PLGA shell of the HM allows the penetration of protons from the outside, activating the hydrolytic cleavage of NONOate, spontaneously generating NO bubbles, which are immediately trapped/stabilized by SC. The SC‐stabilized NO bubbles in the HM are then squeezed through the spaces of its PLGA matrices by the elevated internal pressure. Upon leaving the HM, the entrapped NO molecules may passively diffuse through their SC‐stabilized/protected layer gradually to the tumor site, having a long‐lasting radiosensitizing effect and inhibiting tumor growth. The entire process of NO generation and delivery is conducted in a scavenger (Hb)‐free environment, mimicking the development of young ovoviviparous fish inside their mothers' bodies in the absence of predators before birth.

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Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies

Cited by 311 publications

References 44 publications

Recent Advances in Bioplastics: Application and Biodegradation

Recent Advances in Bioplastics: Application and Biodegradation

Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy

Biomimetic Engineering of a Scavenger‐Free Nitric Oxide‐Generating/Delivering System to Enhance Radiation Therapy

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