The PK parameters for vancomycin in Chinese infants younger than 2 months of age were estimated using the model developed herein. This model has been used to predict individualized dosing regimens in this vulnerable population in our hospital. A large external evaluation of our model will be conducted in future studies.
Population PK models accurately described the PK profiles of piperacillin/tazobactam in infants less than 2 months of age. The results indicated that higher doses or more frequent dosing regimens may be required for controlling infection in this population in NICU.
This paper presents an optimized T-type resonant photoacoustic (PA) cell for methane (CH
4
) gas detection. The noise transmission coefficients and PA field distributions of the T-type resonant PA cell have been evaluated using the finite element method and thermoviscous acoustic theory. The optimized T-type resonant PA cell, together with a near-infrared (NIR) distributed feedback (DFB) laser source, a high-speed spectrometer and a fiber-optic acoustic sensor constitutes a PAS system for CH
4
detection. The sensitivity is measured to be 1.8 pm/ppm and a minimum detectable limit (MDL) of 9 parts per billion (ppb) can be achieved with an averaging time of 500 s. The optimized T-type longitudinal resonant PA cell features of high PA cell constant, fast response time and simple manufacturing process.
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