Background: The incidence and causes of metabolic alkalosis in dogs and cats have not been fully investigated. Objectives: To describe the incidence, nature, and etiology of metabolic alkalosis in dogs and cats undergoing blood gas analysis at a veterinary teaching hospital.Animals: Dogs and cats at a veterinary medical teaching hospital. Methods: Acid-base and electrolyte results for dogs and cats measured during a 13-month period were retrospectively collected from a computer database. Only the first measured (venous or arterial) blood gas analyzed in a single hospitalization period was included. Animals with a base excess above the reference range for the species were included.Results: A total of 1,805 dogs and cats were included. Of these, 349 (19%) were identified as having an increased standardized base excess, 319 dogs and 30 cats. The mixed acid-base disorder of metabolic alkalosis with respiratory acidosis was the most common abnormality identified in both dogs and cats. Hypokalemia and hypochloremia were more common in animals with metabolic alkalosis compared to animals without metabolic alkalosis. The 4 most commonly identified underlying diseases were respiratory disease, gastrointestinal tract obstruction, furosemide administration, and renal disease.Conclusions and Clinical Importance: Metabolic alkalosis was less common than metabolic acidosis in the same population of animals. Evidence of contraction alkalosis was present in many patients in this study. Hypokalemia and hypochloremia were more frequent in patients with metabolic alkalosis and suggest the importance of evaluation of acid-base status in conjunction with serum electrolyte concentrations.
Story Appraisal Theory posits that reduced memory representations of stories, or story kernels, are appraised in a three-dimensional story appraisal space. Stories deemed to have a point (pointedness), to be plausible (plausibility), and to be generalizable to society (probative value) are more likely to provoke implications than stories found wanting on one or more of these appraisal parameters. Story kernel–prompted implications, in turn, produce attitudinal and behavioral effects. Stories may have implications for the self, others (family and friends), and society. Four experiments found general support for the proposition that favorable appraisals promote implication generation. Experiments 2 to 4 revealed that implications partially mediate between the story appraisal dimensions and estimates of behavior change in response to the stories.
Research has shown that perceived message effectiveness (PE) correlates reasonably well with indices of actual effectiveness, but little attention has been given to how to interpret mean PE. This article describes the problem of mean validity and presents a research design that can be used to address it. Participants (N = 195) viewed messages that advocated being screened for colorectal cancer. The results showed downward bias in PE among members of the non-target audience (persons younger than 50) and upward bias as the referent for the judgment became more abstract/distant (self vs. persons older than 50 vs. general). The need for more research on mean validity is discussed. For applied researchers, recommendations for preferred indices of PE are offered.
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