These results suggest that elderly patients aged 80-85 years with advanced gastric cancer could expect a better prognosis with surgical resection. However, extreme-elderly patients aged ≥86 years should consider the risks and benefits of surgical treatment.
Objectives Terlipressin is safely used for acute variceal bleeding. However, side effects, such as hyponatremia, although very rare, can occur. We investigated the development of hyponatremia in cirrhotic patients who had acute variceal bleeding treated with terlipressin and the identification of the risk factors associated with the development of hyponatremia. Design and Methods This retrospective, case-control study investigated 88 cirrhotic patients who developed hyponatremia and 176 controls that did not develop hyponatremia and were matched in terms of age and gender during the same period following terlipressin administration. Results The overall change in serum sodium concentration and the mean lowest serum sodium concentration were 3.44 ± 9.55 and 132.44 ± 8.78 mEq/L during treatment, respectively. Multivariate analysis revealed that baseline serum sodium was an independent positive predictor, and the presence of baseline serum creatinine, HBV, DM, creatinine, and shock on admission was independent negative predictors of hyponatremia (P < 0.05). Conclusion The presence of HBV, DM, the baseline serum sodium, shock on admission, and especially baseline creatinine may be predictive of the development of hyponatremia after terlipressin treatment. Therefore, physicians conduct vigilant monitoring associated with severe hyponatremia when cirrhotic patients with preserved renal function are treated with terlipressin for variceal bleeding.
The prognosis of gallbladder (GB) cancer is very poor because it usually presents at an advanced and incurable stage. 5 year survival rate of progressed GB cancer more than stage III has been estimated below 10%, while 5 year survival rate of stage 0 has been over 80%. 1 Early stage of GB cancer has been usually detected incidentally and the rate of incidental GB cancer after cholecystectomy was reported approximately 0.54-2.1%. 2,3 GB polyp, one of the risk factors of GB cancer, has extremely increasing along with the use of transabdominal ultrasonography. Most of small polyps less than 10mm are benign and remain stable for a long period. 4,5 However, it is
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