Abstrak Pepaya termasuk tanaman yang memiliki banyak manfaat yang dapat bermanfaat dalam pengobatantradisional, terutama daunnya karena mengandung enzim papain yang digunakan untuk mengobati berbagaipenyakit. Bakteri Salmonella typhi berbentuk batang Gram-negatif, tidak punya spora, bergerak dengan flagelperitrik dan kebanyakan ditemukan diusus manusia. Tujuan dari penelitian inidilakukan adalah untuk ujiefektivitas ekstrak daun pepaya (Carica papaya L) terhadap Salmonella typhi pada konsentrasi ekstrak 25%,50%,75% dan 100% dengan perbandingan Chloramfenikol. Penelitian ini dilakukan dengan menggunakanmetode eksperimental laboratorium dengan cara difusi kertas cakram untuk menghitung diameter pada zonahambat dengan menggunakan analisis uji One Way Anova. Hasil yang diperoleh menunjukkan bahwakonsentrasi 25%, 50%, 75% dan 100% dengan rata-rata 7,55 mm, 7,60 mm10,90 mm dan 11,70 mm dapatmenghambat ekstrak daun pepaya (Carica papaya L) dengan menggunakan kontrol positif chloramphenicol 30μ dengan hasil yang lebih besar dari pada kontrol negatifKata kunci: Daun pepaya, Salmonella typhi, kloramfenikol 30 µ
This study aims to test the effectiveness of garlic bulbs on alloxan-induced blood glucose levels in mice. The method used is an actual experimental pretest-posttest control group design. The study revealed that garlic extract could reduce blood glucose levels in mice (p 0.05). The most doses of garlic extract that reduced blood glucose levels in diabetic mice were 6 mg/200 g BW and 12 mg/200 g BW. In conclusion, garlic extract significantly reduced blood glucose levels in diabetic mice when administered at 6 mg/200 g BW and 12 mg/200 g BW. Keywords: Allin, Allisin, Anti Diabetes, Garlic
Hypercholesterolemia is a condition in which cholesterol levels in the blood are more than normal. Europe and America are the regions with the highest hypercholesterolemia in the world with prevalence values of 54% and 48%, respectively. Meanwhile, Africa and Southeast Asia are regions with the lowest prevalence of hypercholesterolemia with prevalence values of 23% and 30%, respectively. In Indonesia, the age group of 25 - 34 years has the highest rank with high cholesterol levels. The purpose of this study was to determine the effect of lowering total cholesterol in male white rats (Rattus norvegicus) induced with Propylthiouracil (PTU). In this study, we used 25 rats which were divided into 5 groups equally. The groups were a negative control group (Na-CMC), a positive control group (Simvastatin), and three extract groups with doses of 500 mg/kgBW, 750 mg/kgBW, and 900 mg/kgBW. We made the ethanol extract of the bark of the Mangkokan stem by maceration. We induced all mice used in the study orally using a high-fat diet and PTU. In this study, the parameters that we studied were total cholesterol levels before induction, after induction, and after treatment. From this study, we found that all groups showed significant changes in total cholesterol levels (P value = 0.000). The group that was given ethanol extract at doses of 500 and 750 mg/kgBW showed a significant difference between the negative control group and the positive control group. Only the 900 mg/kgBW dose group showed no significant difference in total cholesterol levels with the positive control group. Thus, we can conclude that the ethanolic extract of the bark of the Mangkokan stem has the potential to reduce total cholesterol levels but is not as good as the positive control. Kata kunci : Kadar kolesterol total, Kulit batang mangkokan, PTU
Body mass index (BMI) is a simple method that is commonly used to determine whether a person is obese or not. Diabetes mellitus is a disorder of the metabolic system because the pancreas cannot produce enough insulin or the body's cells cannot use insulin effectively. Diabetic foot is one of the chronic complications of diabetes mellitus (DM). Diabetic foot begins with hyperglycemia which causes abnormalities in neuropathy and blood vessels, causing infection. To determine the proportion of body mass index in patients with diabetes mellitus, to determine the prevalence of diabetic feet and non-foots. The research design used in this study is observational analytic. There is a relationship between body mass index and the risk of diabetic foot in type 2 DM patients at Royal Prima Hospital. Prevalence of body mass index 23. 0 in DM Type 2 at Royal Prima Hospital Medan in 2018-2020 reached 70%. The prevalence of diabetic foot in Type 2 DM at the Royal Prima Hospital Medan in 2018-2020 reached 54%.
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