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13,14-Dihydroxy-8,11,13-podocarpatrien-7-one (1) and a series of ring C aromatic diterpene derivatives were synthesised from (+)-manool (4) and evaluated for their cytotoxic, leishmanicidal and trypanocidal activities. Our results indicated that compound 1 and other podocarpane-type intermediates are cytotoxic. Cleavage of C6-C7 bond of compound 7 improved cytotoxic activity, indicating that, in particular, the 6,7-seco-podocarpane-type compound 20 might serve as a lead compound for further development.

Vanadium catalysts supported on Al(Zr)-MCM-41-type materials were prepared by impregnation. Textural and structural properties, elemental composition and electronic structure were determined by N 2 physisorption, small-angle XRD, SEM-EDX and UV-vis DRS, respectively. Al-containing materials showed mostly of Al framework and a small fraction of Al extra-framework species. Zr-containing materials presented almost exclusively small clusters of Zr x O y covering the MCM-41 matrix. Vanadium catalysts, showed the presence of isolated V 5+ species and to a lesser extent polymeric chains likely as small crystallites of V 2 O 5. The catalytic results revealed that VAlM30 catalyst, characterized by a Si/Al atomic ratio of 30, was the most active in thiophene hydrodesulfurization, which could be associated to better textural properties and high dispersion of the vanadium species.

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