Synthesis and investigation of PLGA-based nanoparticles as a modern tool for the drug deliveryThe possibility of immobilization of the «Tamoxifen» antitumor drug in polylactide glycolide nanoparticles was shown in this study. Nanoparticles based on a biodegradable and biocompatible polylactide glycolide polymer were prepared by the simple emulsion method. Various concentrations of the drug substance and stabilizer were studied to obtain nanoparticles with the best physico-chemical parameters (particle size, polydispersity, degree of binding and release, biodegradation). Polyvinyl alcohol was used as a stabilizer in the present work. The sizes of polymer nanoparticles determined by dynamic light scattering vary from 226.7 nm to 397.2 nm with a narrow size distribution (the polydispersity (PDI) values were 0.01-0.2). The degree of «Tamoxifen» binding to the polymer calculated by the UV spectrophotometric method ( = 275.5 nm) was about 82 %, which makes it promising for application in drug delivery. The shape and morphology of nanoparticles were studied with the help of scanning electron microscopy. The kinetics of drug release from polylactide glycolide nanoparticles was studied under conditions simulating a biological medium. The general character of the biodegradation of polylactide glycolide nanoparticles immobilized by «Tamoxifen» was also studied by a viscometric method at different pH values and at 310 К.
One of the promising and inexpensive types of raw materials, taking into account the use of modern technologies for the production of sealing and adhesive materials, are unsaturated polyesters of various compositions.The aimof this work is to study the reaction of radical copolymerization of polyethylene(propylene)-glycolfumarate with acrylic acid in a dioxane solution at various molar ratios of the initial polymer-monomer mixture. Methodology.The composition of the copolymers was identifiedby HPLC spectroscopy by analyzing the mother liquors, the structure was confirmed by IR spectroscopy. The copolymerization kinetics was studied by the dilatometric method. The degree of swelling of the copolymers was determined by the gravimetric method, and their degree of unsaturation, by the bromid-bromate method. Radical copolymerization constants calculated by the Mayo-Lewis integral method.The results obtainedindicate thatfor any composition of the initial polymer-monomer mixture, the composition of the copolymer is enriched with acrylic acid links, and with an increase in its content in the initial polymer-monomer mixture, the reaction rate increases significantly.An increase in the content of unsaturated polyester in the initial polymer-monomer mixture leads to a decrease in the ability of the copolymer to absorb moisture, which makes it possible to assume their use as bases in the production of sealing and adhesive materials. Conclusion. An analysis of the numerical values of the copolymerization constants showed a higher activity of acrylic acid in comparison with unsaturated polyesters, thereby confirming the previously put forward assumption aboutthe relatively lower reactive ability of the latter.
Synthesis and characteristics of metal-polymer complexes of p-EGM/AA-Ni 0-Co 0 and p-PGM/AA-Ni 0-Co 0 Possibility of using the copolymers of poly-(ethylene)-propylene glycol maleate (p-EGM, p-PGM) with acrylic acid (АA) as a matrix for obtaining effective metal-polymer complexes of different application was shown. The compositions, structures and dimensions of particles of nickel and cobalt stabilized in polymeric matrix were determined using the methods of transmission electron microscopy and scanning microscopy, infrared spectroscopy, laser-emission spectroscopy, dispersive microscopy and thermogravimetric analysis. The average size of nanoparticles, which have spherical shape and equal distribution along cross-section of polymer, was 100-170 nm. Percentage content of nickel and cobalt in the complex was equal to 0.52 and 0.48, respectively, in the p-EGM/AA copolymer, 0.49 and 0.51 in the p-PGM/AA copolymer. The analysis of electromagnetic force-pictures of p-EGM/AA (14.8:85.2 mass.%) and p-PGM/AA (15.1:84.9 mass.%) copolymers' films showed a relatively equal distribution of the filler (Ni 0 , Co 0) along the cross-section of polymer. The average number of metal particles on 10 microns was 600-700 units for particles of Ni and 550-650 units for particles of Co. Thermal decomposition of metal-polymer complexes occurred in the temperature range of 200-500 ºС. The average weight loss on TG-curves was 80 %. Therefore, p-EGM/AA-Ni 0-Co 0 and p-PGM/AA-Ni 0-Co 0 metal-polymeric complexes obtained can be used as a template for the creation of catalytically effective composite materials.
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