Abstract:Objective: To examine the changes in serum copper (Cu) levels in benign and malignant thyroid disease in humans. Background: Thyroid hormones infl uence the metabolism of trace elements including copper. Methods: 47 papillary thyroid cancer and 43 benign multinodular goitre patients who underwent total thyroidectomy and 37 healthy control subjects were included into this study. All of the patients and controls were females. Serum Cu levels were detected with atomic absorption spectrophotometer. Results: In the papillary thyroid cancer group serum level of Cu was 131.61±33.9 μg/dL before surgery and 120.81±30.4 μg/dL after 20 days from surgery. In the benign group serum Cu level was 84.75±12.1 μg/dL and 68.01±9.4 μg/dL postoperatively.These results were compared to healthy control's value of 105.87±10.68 μg/dL. In the papillary thyroid cancer group pre-and postoperative serum Cu level was signifi cantly higher when compared to control group (p<0.05). Postoperative serum Cu level signifi cantly decreased when compared to pre-operative level(p<0.05), in which, it was still higher than the control(p<0.05). In the benign group pre-and postoperative serum Cu level was significantly lower than in the control group (p<0.05).Postoperative serum Cu level signifi cantly decreased when compared to pre-operative level in the benign group (p<0.05). Conclusion: This is a pioneer study to examine serum Cu level in benign and malignant thyroid patients compared to controls. In our small groups serum Cu levels increased in malignant thyroid patients and decreased in the benign group (Tab. 1, Ref. 18 Trace elements are essential micro-nutrients both for humans and other organisms. They are crucial for many physiological processes and are involved in many pathologic changes in tissues (1). Thyroid hormones infl uence the metabolism of trace elements including copper (Cu) (2). Cu is important for the activity of the enzyme superoxide dismutase (SOD). Changes in the activity of this enzyme are consistent with the Cu serum levels (3). Cu was shown to be essential for cell division both in normal and cancerous tissue (4, 5). Although copper is an essential element for human and animals, a high concentration of Cu (above normal) could induce growth proliferation and cancer by damaging DNA with toxic free hydroxyl radicals (6).The present study was undertaken to investigate correlation of Cu serum levels in benign and malign thyroid diseases before and after surgery compared to controls. Materials and methodsThis is an age-and sex-matched case-control study, conducted at the Department of Medical Biochemistry of Celal Bayar University of Medicine and the Department of General Surgery of Ankara Oncology Hospital, Ankara, Turkey. The study was approved by the hospital Ethical committee. All the patients and the volunteers involved in the study have given informed consent. PatientsRecruitment of subjects was performed by convenience sampling at outpatient General Surgery Clinic of Oncology Hospital, Turkey by trained physicians. 47...

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Thyroid nodules that are reported in cytology as Hürthle cell lesions require surgery to differentiate benign from malignant disease.

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Hydatid cyst disease in bone is a rare one (0.5-2.5%) and 30% is seen in the pelvis. This disease is difficult to diagnose as symptoms are similar to the bone malignancy. Forty five years old female patient was admitted to another hospital with the complaints of pain in lower-right quadrant of the abdomen radiating to the right leg. She had a palpable mass in this region and was sent to our hospital with a prediagnosis of bone malignancies. During the physical examination, a mass about 8×10 cm semifixed to the right iliac bone was palpated. Serum tumor markers were within normal limits. Findings in magnetic resonance imaging was compatible with stage 3-4 hydatid cyst disease and also it was reported that cystadenocarsinoma should be considered in the differential diagnosis. Serological examination and fine needle aspiration biopsy were performed. Indirect hemagglutination test titer 1/2048(+) and biopsy results were consistent with hydatid cyst. Fifteen days prior to the surgery, the patient was given 10mg/kg albendazole treatment. Mass containing daughter vesicles caused bone destruction in iliac bone were totally scraped.Pirhan Y., Kurt N.

Elli dört yaşında erkek hasta, 8 saat önce başlayan sol kasıkta sürekli ağrı ve redükte olmayan şişlik şikayeti ile acil cerrahi servisine başvurdu. Fiziksel incelemede karında hassasiyet yoktu, sol kasıkta oldukça ağrılı, eritemli ve redükte olmayan şişlik vardı. Rutin kan testlerinde hafif lökositoz saptandı. Düz karın grafisinde özellik yoktu, ultrasonografide sol inguinal kanalda 10 cm uzunluğunda, hareketsiz, ödemli ince bağırsak ansı görüldü. Boğulmuş sol kasık fıtığı tanısıyla hasta ameliyata alın-dı. Kasığa transvers kesi yapılarak fıtık kesesi ortaya konuldu. Kese açıldığında 6-8 cc pürülan sıvı geldi, vermiform apendiks inflame ve kese iç duvarına yapışık durumdaydı. Aynı seansta hem apendektomi hemde primer fıtık onarımı yapıldı. Ameliyat sonrası komplikasyon gelişmedi. Patolojik inceleme inflame apendiks ile uyumluydu.Anahtar Sözcükler: Amyand fıtığı; sol taraf; cerrahi tedavi.A 54-year-old male complained of a continuous pain together with an irreducible swelling of the left inguinal region 8 hours prior to admission to the surgical emergency department. His physical examination revealed a very painful, erythematous, irreducible swelling in the left inguinal region without abdominal peritoneal irritation. Routine blood tests disclosed mild leukocytosis. Abdominal plain X-ray film was not specific, and ultrasonography revealed a 10 cm in length inactive, edematous intestinal section within the inguinal hernia. With the diagnosis of strangulated inguinal hernia, he underwent surgical exploration through a transverse inguinal incision. By opening the hernia sac, 6-8 cc inflammatory fluid drained out, and an inflamed vermiform appendix adhered to the inner surface of the sac was seen. Appendicectomy and primary hernia repair were performed at the same time through the inguinal incision. The postoperative course was uneventful, and the histological examination of the specimen revealed an inflamed appendix.

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