Objective: The aim of this study is to evaluate and compare arterial stiffness, which is an independent risk indicator for cardiovascular diseases (CVDs), between patients with overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism by antithyroid therapy and healthy volunteers with pulse wave analysis (PWA). Subjects and methods: A total of 102 volunteers were included in the study (30 in the overt hyperthyroid group, 28 in the subclinical hyperthyroid group and 14 with euthyroidism by antithyroid therapy and 30 healthy). The arterial stiffness measurements of the participants in the study were performed with the Mobil-O-Graph PWA device (I.E.M. GmBH, Stolberg, Germany), which makes cuff based oscillometric measurement from the brachial artery. Results: Systolic blood pressure, pulse rate, central systolic blood pressure, cardiac output, heart rate-corrected augmentation index (Aix@75) and pulse wave velocity (PWV) measurements were significantly higher in the hyperthyroid group than in the control group. The heart rate and PWV in the subclinical hyperthyroid group were significantly higher than the control group. In the euthyroid group, systolic blood pressure, central systolic blood pressure, cardiac output, cardiac index and PWV were found significantly higher than the control group. There was also a negative correlation between Aix@75 and thyroid-stimulating hormone (TSH), and a positive correlation between Aix@75 and free thyroid hormones. Conclusion: In our study, we observed that the arterial stiffness was adversely affected by an overt or subclinical increase in thyroid hormones and this correlated with thyroid hormone levels. We recommend that PWV measurement, which is a simple method for detecting CVD risk, can be used in these patients.
We found that PWV was significantly higher in patients with euthyroid nodular goiter. This result suggests that these patients may be at risk for cardiovascular disease.
Objective: The aim of this study is to evaluate and compare arterial stiffness, which is an independent risk indicator for cardiovascular diseases (CVDs), between patients with overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism by antithyroid therapy and healthy volunteers with pulse wave analysis (PWA). Subjects and methods: A total of 102 volunteers were included in the study (30 in the overt hyperthyroid group, 28 in the subclinical hyperthyroid group and 14 with euthyroidism by antithyroid therapy and 30 healthy). The arterial stiffness measurements of the participants in the study were performed with the Mobil-O-Graph PWA device (I.E.M. GmBH, Stolberg, Germany), which makes cuff based oscillometric measurement from the brachial artery. Results: Systolic blood pressure, pulse rate, central systolic blood pressure, cardiac output, heart rate-corrected augmentation index (Aix@75) and pulse wave velocity (PWV) measurements were significantly higher in the hyperthyroid group than in the control group. The heart rate and PWV in the subclinical hyperthyroid group were significantly higher than the control group. In the euthyroid group, systolic blood pressure, central systolic blood pressure, cardiac output, cardiac index and PWV were found significantly higher than the control group. There was also a negative correlation between Aix@75 and thyroid-stimulating hormone (TSH), and a positive correlation between Aix@75 and free thyroid hormones. Conclusion: In our study, we observed that the arterial stiffness was adversely affected by an overt or subclinical increase in thyroid hormones and this correlated with thyroid hormone levels. We recommend that PWV measurement, which is a simple method for detecting CVD risk, can be used in these patients.
Nefropatisi olan ve olmayan diyabetli hastalarda serum prokalsitonin (PCT) düzeylerinin nasıl etkilendiğini araştırarak bu hastalarda PCT'nin bir enflamasyon göstergesi olup olamayacağını belirlemektir. Gereç ve Yöntem: Çalışmaya 175 hasta [75 diyabetik nefropati (grup 1), 75 nefropatisi olmayan diyabetik (grup 2) ve 25 non-diyabetik nefropati (grup 3)] ve 75 sağlıklı gönüllü dahil edildi. Hasta ve kontrol gruplarının serum ve üriner kreatinin, serum high sensitive C-reaktif protein (hsCRP), PCT, beyaz küre, nötrofil, HbA1c ve üriner protein değerleri elde edildi. Üriner protein/kreatinin oranı ve eGFR hesaplandı. Bulgular: Grup 1, 2 ve 3 ile kontrol grubunun PCT değerleri (sırasıyla 0,20-0,19-0,23 ve 0,19) arasında anlamlı bir fark yoktu (p>0,05). Her 3 hasta grubunun hsCRP düzeyleri ise kontrol grubundan yüksekti (p<0,001). Nefropatili hastaların (diyabetik ve non-diyabetik) GFR değerleri ile PCT (p<0,001; r =-0,475) ve hsCRP (p<0,001; r=-0,415) değerleri arasında negatif korelasyon saptandı. Diyabetik nefropatili hastalarda GFR 60 ml/dk'nın altında olanlarla GFR 60 ml/dk ve üzerinde olanlar karşılaştırıldığında; GFR değerleri 60 ml/dk'dan düşük olanların hsCRP değerleri daha yüksek iken (p<0,05); PCT değerleri arasında fark yoktu (p>0,05). Sonuç: Diyabetli ve diyabetik nefropatili hastaların PCT değerlerinde anlamlı bir artış yoktu. Ancak PCT düzeyi ile GFR arasında negatif korelasyon mevcuttu. Bu durum özellikle ileri evre kronik böbrek hastalığında, etiyolojik nedenden bağımsız olarak PCT değerlerinde artış olabileceğini göstermektedir.
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