An assessment of the relationship between thyroid nodule characteristics, insulin resistance and arterial stiffness in euthyroid nodular goiter

Aydoğan, Yasemin; Altay, Mustafa; Ünsal, Oktay; Kaplanoğlu, Veysel; Çağır, Yavuz; Yıldız, Canan; Beyan, Eśin; Ramadan, Selma Uysal

doi:10.1007/s12020-018-1701-6

Cited by 5 publications

(7 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were also differences between the groups in terms of HOMA-IR and insulin level. HOMA-IR did not correlate with thyroid volume, nodule volume and nodule count 30 . While a prospective study not found difference in thyroid volume or the presence of nodular thyroid diseases among the groups with presence or absence of insulin resistance.…”

Section: Discussionmentioning

confidence: 71%

Association between metabolic syndrome and euthyroid nodular goiter: a case-control study

et al. 2019

View full text Add to dashboard Cite

Background: Metabolic syndrome is a cluster of metabolic abnormalities and abdominal obesity; its pathophysiologic basis, insulin resistance, has been shown to act as agent in thyroid cell proliferation. Few studies analyze the relationship between metabolic syndrome and thyroid nodular disease, with a substantial knowledge gap. Objetive: Determine the association between metabolic syndrome and nodular thyroid disease in a region with adequate iodine intake. Methods: Case-control study. A total of 182 patients referred to radiology to undergo thyroid ultrasonography due to suspicion of thyroid disease. Cases had at least one thyroid nodule greater than 3 mm (n= 91). Controls did not have evidence of thyroid nodules (n= 91). Results: Bivariate analysis showed a significant association between metabolic syndrome and the presence of thyroid nodule (OR 2.56, 95% CI: 1.41-4.66, p <0.05). Low levels of HDL (OR 2.81, 95% CI: 1.54-5.12, p <0.05) and impaired fasting glucose (OR 2.05, 95%CI 1.10 to 3.78, p <0.05) were significantly associated with the presence of thyroid nodule, independent of the presence of metabolic syndrome. Multivariate analysis maintained the association between metabolic syndrome and thyroid nodule with an OR of 2.96 (95%CI 1.47 to 5.95, p <0.05); similarly, the associations of low levels of HDL (OR 2.77, 95%CI 1.44 to 5.3, p <0.05) and impaired fasting glucose (OR 2.23, 95%CI 1.14 to 4.34, p<0.05) with thyroid nodule remained significant. Conclusion: The thyroid nodular disease is associated with increased risk of metabolic syndrome, specifically decreased HDL and impaired fasting glucose levels were the factors that increased association was found.

show abstract

Section: Discussionmentioning

confidence: 71%

Association between metabolic syndrome and euthyroid nodular goiter: a case-control study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In terms of insulin resistance [IR] evaluation, most of the prior studies evaluated IR using HOMA-IR [19] .…”

Section: Discussionmentioning

confidence: 99%

Thyroid Function in Euthyroid subjects and Its Association with Insulin Resistance

Elsheref

El-Samee

Abdulrehim

et al. 2021

International Journal of Medical Arts

View full text Add to dashboard Cite

Article information Background: Diabetes mellitus [DM] and thyroid dysfunction are the most commonly coexistent disorders. Hypo-and hyperthyroidism are causes of dysglycemia. However, the relation between normal thyroid hormone levels and insulin resistance [IR] is unclear. The aim of the work: This study aimed to examine the association between the normal values of thyroid hormones and glucose metabolism and to investigate whether improvement of metabolic status can restore thyroid function in patients with uncontrolled type-2 diabetes mellitus [T2DM]. Patients and Methods: This study was a retrospective observational study. A total of 120 euthyroid participants were recruited. They were classified into four groups: Normal glucose tolerance [NGT, n =28], Prediabetes [n=32], well controlled DM [T2DM with glycated hemoglobin [HbA1c] ≤ 7%, n =26], and uncontrolled DM [T2DM with HbA1c > 7%, n = 34]. The results were compared between groups and the changes before and after treatment in uncontrolled DM group were observed and documented. Results: A total sample of 120 participants showed that mean age of DM uncontrolled patients was 40.2± 19.5 and there were no significant differences among groups regarding their age, body mass index [BMI], blood pressure [BP]. However, groups showed significant differences regarding cholesterol, free t4, serum glucose, two hours post prandial glucose, HbA1c, fasting insulin and insulin resistance. Regression analysis revealed that BMI, HbA1C, low density lipoprotein [LDL], triglycerides [TG] and total thyroxine [TT4] had statistically significant association with insulin resistance. there is statistically significant difference between uncontrolled DM patients before and after treatment regarding HbA1C and glucose. Conclusion: Reduced levels of free thyroid hormones [although in normal range] were significantly associated with high levels of serum glucose and HOMA-IR. There was significant improvement of blood glucose levels and insulin resistance.

show abstract

“…We preferred arterial stiffness measurement to detect cardiovascular risk in the patients with hypoparathyroidism. Since validity and reliability of this method was shown in many studies, we also used it to detect cardiovascular risk in some endocrinological diseases in our previous studies (32)(33)(34)(35). Increase of the experiences and researches on this topic shows that arterial stiffness method which is easy and noninvasive to implement shall gradually enter into medical practice routine.…”

Section: Discussionmentioning

confidence: 99%

Central and peripheral blood pressures and arterial stiffness increase in hypoparathyroidism

Pamuk¹,

Akkan²,

Dağdeviren³

et al. 2020

Archives of Endocrinology and Metabolism

Self Cite

View full text Add to dashboard Cite

Objective:The aim of the present study was to evaluate whether arterial stiffness is affected in the patients with hypoparathyroidism through pulse wave analysis (PWA). Subjects and methods: Sixty-three patients diagnosed with hypoparathyroidism and sixty volunteers were evaluated for the study. When 21 patients were excluded in the hypoparathyroidism group due to exclusion criteria, the research continued with 42 patients and 60 volunteers who are similar to the patients in terms of age, gender and body mass index (BMI). Fasting plasma glucose after 10 hours of fasting, creatinine, thyroid stimulating hormone (TSH), free thyroxine (fT4), albumin, calcium, phosphorus, magnesium, 25-OH vitamin D, parathormone (PTH) and urine calcium results in 24-hour urine for the patients in the hypoparathyroidism group were recorded. Evaluation of arterial stiffness was performed by Mobil-O-Graph 24h PWA device. Results: Systolic blood pressure (SBP) (p = 0.01), diastolic blood pressure (DBP) (p = 0.005), mean blood pressure (p = 0.009), central SBP (p = 0.004), central DBP (p = 0.01) and pulse wave velocity (PWV) (p = 0.02) were found higher in the hypoparathyroidism group. A positive correlation was detected between phosphorus level and SBP [(p = 0.03. r = 0.327)], central SBP [(p = 0.04, r = 0.324)] and PWV [(p = 0.003, r = 0.449)]. We detected that age and serum phosphorus levels were independent predictor variables for PWV (B = 0.014, p < 0.001 and B = 0.035, p < 0.001, respectively). Conclusion: We detected that hypoparathyroidism causes an increase in blood pressure and arterial stiffness. The most significant determinant factors were detected as advanced age and hyperphosphatemia. The patients diagnosed with hypoparathyroidism should be closely monitored and treatment planning should include to prevent the patients from hyperphosphatemia.

show abstract

An assessment of the relationship between thyroid nodule characteristics, insulin resistance and arterial stiffness in euthyroid nodular goiter

Abstract: We found that PWV was significantly higher in patients with euthyroid nodular goiter. This result suggests that these patients may be at risk for cardiovascular disease.

Cited by 5 publications

References 41 publications

Association between metabolic syndrome and euthyroid nodular goiter: a case-control study

Association between metabolic syndrome and euthyroid nodular goiter: a case-control study

Thyroid Function in Euthyroid subjects and Its Association with Insulin Resistance

Central and peripheral blood pressures and arterial stiffness increase in hypoparathyroidism

Contact Info

Product

Resources

About