Extensive studies on hepatitis C have been conducted since Limited information is available regarding the histology of the specific serological test for hepatitis C virus (HCV) infechepatitis C virus infection in children. The aim of this study tion was developed, and the characteristics of this disease was to determine the histological pattern of chronic hepatitis have been established. [1][2][3][4] Recent pathological studies have C (CHC) in children, and liver biopsy specimens from 109 clearly defined the histological characteristics of chronic heppediatric patients with CHC were examined. Each biopsy atitis C (CHC), e.g., lymphoid aggregates in the portal tract, specimen was evaluated based on a numerical scoring system bile duct damage, and large-droplet fatty changes, in comparfor the stage of fibrosis (1-4), the grade of portal/periportal ison to chronic hepatitis B (CHB). [5][6][7] However, in-depth studnecroinflammation (0-4), the grade of lobular necroinflammaies of CHC in children have not been conducted, and the tion (0-4), and their sum (final grade). The histological lesions histological characteristics of this disease in pediatric patients considered to be characteristic of chronic hepatitis were also remained to be identified, although it is well known that evaluated. None of the children had liver cirrhosis, and 105 even pediatric patients with CHB have various degrees of cases (97%) were stage 1 or 2. Only 4 children were stage 3.hepatic lesions ranging from mild fibrosis to liver cirrhosis. 8 Two of these 4 cases showed hemosiderosis. A significant Some studies have reported histopathology of CHC in pediatcorrelation was observed between the staging score and the ric patients, 9-13 but they examined only a small number of final grade in the pediatric patients (r Å .59; P õ .0001). The liver biopsy specimens, and their histological evaluation histological characteristics of adult CHC, such as lymphoid methods differed. For example, Inui et al. 9 examined the aggregate, bile duct injury, and fatty changes, were also obliver biopsy specimens of 25 pediatric patients with CHC served in the children. In conclusion, the majority of children who were all transfusion associated, but the investigators did with CHC presented with mild fibrosis, but a few showed not find liver cirrhosis. In contrast, Lai et al. 10 followed up CHC with lobular distortion and hemosiderosis. Frequent 46 thalassemic children who were treated with blood transfublood transfusion may aggravate hepatic lesions in pediatric sions and found that 5 patients (11%) developed liver cirrho-CHC. (HEPATOLOGY 1997;26:771-775.) sis during the following 8 years.The present study was designed to clarify the histological changes in the liver of pediatric patients with CHC. PATIENTS AND METHODSAbbreviations: HCV, hepatitis C virus; CHC, chronic hepatitis C; CHB, chronic hepatitis B.Patients. We collected 109 biopsy specimens from 109 pediatric men and 62 women who ranged in age from 23 to 95 years old Received September 27, 1996; accept...
To determine the incidence of hepatitis C virus (HCV) infection in patients with alcoholic liver disease (ALD), serum samples from 252 patients with ALD were tested for anti-HCV and HCV RNA. Serial sera of these patients were collected and stored under optimal conditions to allow exact quantification of HCV RNA. Fifteen patients who visited our hospital during the same period of time with chronic HCV infections served as controls. In those with ALD, anti-HCV and HCV RNA were positive in 55.5% and 41.2%, respectively. Patients with histologically diagnosed chronic hepatitis and hepatocellular carcinoma had much higher prevalence rates of HCV RNA (84% and 100%, respectively) compared to those with fatty liver (4.3%), hepatic fibrosis (10.1%) and alcoholic hepatitis (22.2%) (P < 0.01). Although no difference in serum HCV RNA levels was observed between the patients with both ALD and chronic HCV infection and those with chronic HCV infection alone, HCV RNA levels significantly (10-fold) dropped after abstinence in nearly half of the patients (P < 0.01). These data indicate that HCV infection in patients with ALD promotes progression of liver disease, and abstinence from alcohol is associated with a reduction in serum HCV RNA levels.
Anorexia nervosa is an eating disorder characterized by a fear of weight gain and a preoccupation with body image. Although hepatic involvement has been reported in patients with anorexia nervosa, the mechanismis not fully understood. Wedescribe a patient with anorexia nervosa with liver function abnormalities. Light and electron microscopic observations revealed a remarkable accumulation of glycogen in hepatocytes. These results suggest that adaptive responses to starvation mayalter carbohydrate metabolismin patients with anorexia nervosa. (Internal Medicine 37: 678-682, 1998)
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