The incidence of hepatocellular carcinoma in patients with chronic hepatitis C after interferon treatment.

Miyajima, Ichiro; Sata, Michio; Kumashiro, Ryukichi; Uchimura, Yasuyo; Ide, Tatsuya; Suzuki, Hiroshi; Tanikawa, Kyuichi

doi:10.3892/or.5.1.201

Cited by 15 publications

(14 citation statements)

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“…To determine the relationship between the efficacy of IFN therapy and HCC, it is necessary to calculate the number of patients meeting statistical relevance and to perform a randomized controlled study. Age [12,13], sex [12], fibrosis [13,14], HCV RNA level [14] were not risk factors in this study. The findings in the present study suggest that patients with Plt counts below the lower limit of normalcy are at high risk of developing HCC even when treated with IFN.…”

Section: Discussionmentioning

confidence: 48%

Analysis of Background Factors Influencing Long-Term Prognosis of Patients with Chronic Hepatitis C Treated with Interferon

Yoneyama

Yamaguchi²,

Kiuchi³

et al. 2002

Intervirology

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Objective: Interferon (IFN) therapy has been used as antiviral therapy for chronic hepatitis C (CH-C); however, complete response to the therapy is observed in only about 30% of patients in Japan. Background factors involved in the responsiveness to IFN therapy, and progression to liver cirrhosis (LC) and hepatocellular carcinoma (HCC) after IFN therapy have not yet been sufficiently investigated. Methods: One hundred twenty-one patients with CH-C who received IFN therapy at Showa University Hospital between 1984 and 1999 were analyzed. Results: At 6 months after the termination of IFN therapy, 53 patients achieved a complete response, 11 patients incomplete response, and 57 patients no response. During a mean follow-up of 52.7 months, 12 patients progressed to LC, and 10 patients developed HCC. Multivariate analysis showed that significant independent factors involved in progression to LC were platelet count and the efficacy of IFN therapy. The significant independent factor involved in the development of HCC was platelet count. The factor involved in the therapeutic effect at 6 months after the termination of IFN administration was the serum hepatitis C virus (HCV) RNA levels before IFN therapy. Conclusion: Patients with high HCV RNA levels and low platelet counts should be considered to be at high risk of progressing to LC and developing of HCC and should be carefully followed after IFN therapy using ultrasonography, CT scan and MRI.

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Section: Discussionmentioning

confidence: 48%

Analysis of Background Factors Influencing Long-Term Prognosis of Patients with Chronic Hepatitis C Treated with Interferon

Yoneyama

Yamaguchi²,

Kiuchi³

et al. 2002

Intervirology

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“…Initial data from both Japan and Europe showed a lower risk of HCC in cohorts of patients with hepatitis C cirrhosis who were given interferon therapy compared with those who were not treated. [134][135][136][137] This effect was irrespective of the antiviral effects of interferon alpha, and was seen with treatment duration of only three months. These studies were not randomised controlled trials and have inherent selection bias.…”

Section: Embolisation/chemoembolisationmentioning

confidence: 84%

Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults

Ryder

2003

Gut

321

294

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“…The incidence of HCC development in these patients is reportedly about 4% and 28% at 3 years and 6 years, respectively 5 . The risk factors for HCC development have been reported to be platelet count, average serum alanine aminotransferase (ALT) level and advanced stage of fibrosis 6–8 …”

Section: Introductionmentioning

confidence: 99%

Occult hepatitis B virus infection as a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C in whom viral eradication fails

Miura¹,

Shibuya²,

Adachi³

et al. 2008

Hepatology Research

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The incidence of hepatocellular carcinoma in patients with chronic hepatitis C after interferon treatment.

Cited by 15 publications

References 0 publications

Analysis of Background Factors Influencing Long-Term Prognosis of Patients with Chronic Hepatitis C Treated with Interferon

Analysis of Background Factors Influencing Long-Term Prognosis of Patients with Chronic Hepatitis C Treated with Interferon

Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults

Occult hepatitis B virus infection as a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C in whom viral eradication fails

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