The pathologic findings of hypertensive hearts a r e represented by myocardial hypertrophy, especially those of the left ventricles, but hypertension without cardiac hypertrophy is not rare. The influence of hypertension is manifested not only as cardiac hypertrophy, but also as acceleration of coronary atherosclerosis.The present report is on some of the results of cardiac measurings, concerning hypertensive and non-hypertensive cases in Part I, and of the study on correlations between hypertension and coronary atherosclerosis in Part 11.The term "hypertensive" is used when the blood pressure had been maintained over 150mmHg in systolic, and 90mmHg in diastolic for a definite time, and had been diagnosed "hypertensive" by some doctor.The cases with organic cardiovascular diseases such as valvular lesions, pericarditis, congenital malformation and aortic aneurysms were excluded. Part 1 Measuring of the hearts MATERIALS The materials used for cardiac measuring were 117 hearts over 10 years of age, collected from autopsy cases at the Kurume University and Beppu National Hospital in Kyushu, Japan, from March 1960 to August 1963. Sixty cases were non-hypertensive (39 males and 21 females), and the remaining 57 were hypertensive (40 males and 17 females).
Using mainly rabbits and rats investigations on the endothelial permeability of the aorta, on relation between thrombus formation and endothelial damage, and on tissue culture of the endothelial cells of the rabbit aorta have been carried out.
The permeability of endothelial layer of rabbit aorta Increased by cholesterol‐feeding. This seems to be derived from morphological and functional disorder of the endothelial cells. As a hemodynamic effect of blood flow, increased permeability of the endothelium of rat aorta was also found in experimental renal hypertension.
Accumulation of blood‐plasma components (edema) was seen in the subendothellal area in cholesterol‐fed rabbit aorta and in hypertensive rat aorta. Long‐standing subendothellal edema is considered to be the cause of fibrous intlmal thickening (Grade I lesion/Nakashlma).
Endothelial defect of the aorta due to various damages is related to thrombus formation, and this seems to be accelerated by cholesterol feeding.
Morphological differences between normal endothelium and that of atherosclerotic lesion in human and in rabbit aortas can be seen.
Tissue culture of the endothelium was performed in vivo and in vitro, and some discussions were made on the characteristics of cultured endothelial cells.
It is well known that metastasis of thyroid carcinoma frequently occurs in the bone. However, cases are rare in which severe general skeletal metastasis are de monstrated and small primary thyroid carcinoma can not be detected clinically. The author will report here an autopsy case of clinically latent thyroid carcinoma with intensive bone and lung metastases. CASE HISTORY The patient: 66 year-old Japanese male. Chief complaint: Complete paralyses of both lower extremities. Past history: Not remarkable.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.