Implication for health policy/practice/research/medical education Middle East pain syndrome is a novel disease, which requires more knowledge on its pathogenesis, prevention, and treatment. Possible cadmium contamination should also be considered. Notably, symptoms of this syndrome improved by fibromyalgia therapy consisting of muscle relaxants and vitamin D3 supplementation, and other related drugs. Therefore, we suggest more attention to this syndrome, in patients with various complaints as mentioned above.
The consequences of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection vary among persons, while some individuals are at high risk. Patients with systemic lupus erythematosus (SLE) and COVID-19 necessitate particular attention. SLE cases may be at particular risk for SARS-CoV-2 due to their dysregulated immune system and immunosuppressive treatments. Organ injury and administration of systemic glucocorticoids and other immunosuppressive agents are the risk factors for severe SARS-CoV-2. Additionally, SLE is not uncommon and could be severe in some ethnicities like African and Hispanic individuals and may be accompanied by poor outcomes of SARS-CoV-2. Thus, knowledge of the triggering immune response and therapeutic modalities in SLE and SARS-CoV-2 is necessary to guide treatment of this serious infectious disease in the background of SLE and vice versa.
This is a cross-sectional investigation, which was carried out on 127 kidney biopsy proven lupus nephritis cases by lupus nephritis classification of ISN/RPS 2003. We studied demographic data of all individuals comprising serum creatinine, 24 hours proteinuria, age and gender. Our study showed no difference of serum creatinine and 24 hours proteinuria and lupus nephritis (LN) classes between age below or equal to 40 versus more than 40 years old. In this study also, we found no significant difference of antibody deposited intensity of IgG, C3 and C1q in immunofluorescence study in age below or equal to 40 versus more than 40 years old. Accordingly, no significant difference of LN classes, activity or chronicity percent between ages below or equal to 40 versus more than 40 years old. Moreover, no significant difference of number of sclerotic glomeruli or crescents among patients with ages below or equal to 40 versus more than 40 years old were detected.
Three different formations of Aloe vera are frequently used in therapeutic applications, which are completely diverse in their biochemical content and beneficial characteristics, latex, gel, and extract. Recently, investigators have employed Aloe vera with new decomposable efficient biomaterials and nanostructures for targeting applications like tissue engineering, drug delivery systems, the remedy of various diseases, the food industry, and the removal of pollutants. Numerous different nanostructures made by Aloe vera for different applications are presented in this review.
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