To correlate neuroer~docrine changes with clinical response, 4 girls (4-7 yrs) and 1 boy age 6 with central precocious puberty were treamd with D-His-A subcutaneously. D-His-A was given at a dose of 4 pglkglday for 4 mos; then, the dose was increased to 8 pglkglday. The children were serially studied at 0, 3, and 6 mos. Blood was analyzed for GH, LH, FSH q 20 min (1800-0600). GnRH (2.5 pglkg IV) tests and response to D-His-A (usual treatment dose sc) were followed. Gonadal steroids fell to prepubertal range in the first 3 mos. Results of mean growth velocity (GV), GH. Somatomedin C, LH and FSH, GnRH and D-His-A Tests are shown: Pretherapy 3 mos. 6 mos.
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