To correlate neuroer~docrine changes with clinical response, 4 girls (4-7 yrs) and 1 boy age 6 with central precocious puberty were treamd with D-His-A subcutaneously. D-His-A was given at a dose of 4 pglkglday for 4 mos; then, the dose was increased to 8 pglkglday. The children were serially studied at 0, 3, and 6 mos. Blood was analyzed for GH, LH, FSH q 20 min (1800-0600). GnRH (2.5 pglkg IV) tests and response to D-His-A (usual treatment dose sc) were followed. Gonadal steroids fell to prepubertal range in the first 3 mos. Results of mean growth velocity (GV), GH. Somatomedin C, LH and FSH, GnRH and D-His-A Tests are shown: Pretherapy 3 mos. 6 mos.
Surgical biopsy has been recommended for all thyroid nodules in children because of the risk of thyroid cancer. Our 3-year experience with fine needle aspiration biopsy of the thyroid (FNA) was reviewed to determine whether some patients with thyroid nodule could be safely followed without surgical biopsy. 17 patients, ranging in age from 5-17 years, received FNA. Based on cytologic and clinical findings, it was determined whether surgery or observation was indicated. The following diagram illustrates the results.
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