IMPORTANCE Social and economic costs of depression are exacerbated by prolonged periods spent identifying treatments that would be effective for a particular patient. Thus, a tool that reliably predicts an individual patient's response to treatment could significantly reduce the burden of depression. OBJECTIVE To estimate how accurately an outcome of escitalopram treatment can be predicted from electroencephalographic (EEG) data on patients with depression. DESIGN, SETTING, AND PARTICIPANTS This prognostic study used a support vector machine classifier to predict treatment outcome using data from the first Canadian Biomarker Integration Network in Depression (CAN-BIND-1) study. The CAN-BIND-1 study comprised 180 patients (aged 18-60 years) diagnosed with major depressive disorder who had completed 8 weeks of treatment. Of this group, 122 patients had EEG data recorded before the treatment; 115 also had EEG data recorded after the first 2 weeks of treatment. INTERVENTIONS All participants completed 8 weeks of open-label escitalopram (10-20 mg) treatment. MAIN OUTCOMES AND MEASURES The ability of EEG data to predict treatment outcome, measured as accuracy, specificity, and sensitivity of the classifier at baseline and after the first 2 weeks of treatment. The treatment outcome was defined in terms of change in symptom severity, measured by the Montgomery-Åsberg Depression Rating Scale, before and after 8 weeks of treatment. A patient was designated as a responder if the Montgomery-Åsberg Depression Rating Scale score decreased by at least 50% during the 8 weeks and as a nonresponder if the score decrease was less than 50%. RESULTS Of the 122 participants who completed a baseline EEG recording (mean [SD] age, 36.3 [12.7] years; 76 [62.3%] female), the classifier was able to identify responders with an estimated accuracy of 79.2% (sensitivity, 67.3%; specificity, 91.0%) when using only the baseline EEG data. For a subset of 115 participants who had additional EEG data recorded after the first 2 weeks of treatment, use of these data increased the accuracy to 82.4% (sensitivity, 79.2%; specificity, 85.5%). CONCLUSIONS AND RELEVANCE These findings demonstrate the potential utility of EEG as a treatment planning tool for escitalopram therapy. Further development of the classification tools presented in this study holds the promise of expediting the search for optimal treatment for each patient.
Visual tracking performance has long been limited by the lack of better appearance models. These models fail either where they tend to change rapidly, like in motion-based tracking, or where accurate information of the object may not be available, like in color camouflage (where background and foreground colors are similar). This paper proposes a robust, adaptive appearance model which works accurately in situations of color camouflage, even in the presence of complex natural objects. The proposed model includes depth as an additional feature in a hierarchical modular neural framework for online object tracking. The model adapts to the confusing appearance by identifying the stable property of depth between the target and the surrounding object(s). The depth complements the existing RGB features in scenarios when RGB features fail to adapt, hence becoming unstable over a long duration of time. The parameters of the model are learned efficiently in the Deep network, which consists of three modules: (1) The spatial attention layer, which discards the majority of the background by selecting a region containing the object of interest; (2) the appearance attention layer, which extracts appearance and spatial information about the tracked object; and (3) the state estimation layer, which enables the framework to predict future object appearance and location. Three different models were trained and tested to analyze the effect of depth along with RGB information. Also, a model is proposed to utilize only depth as a standalone input for tracking purposes. The proposed models were also evaluated in real-time using KinectV2 and showed very promising results. The results of our proposed network structures and their comparison with the state-of-the-art RGB tracking model demonstrate that adding depth significantly improves the accuracy of tracking in a more challenging environment (i.e., cluttered and camouflaged environments). Furthermore, the results of depth-based models showed that depth data can provide enough information for accurate tracking, even without RGB information.
Abstract-In recent years, researches on adaptive control have focused on bio-inspired learning techniques to deal with real-life applications. Reinforcement Learning (RL) is one of these major techniques, which has been widely used in robot control approaches. The implementation of artificial neural networks in RL algorithms enables more efficient optimal control strategies. This article proposes a field application of neural network reinforcement learning (NNRL) for walking control of an active simulated 3-link biped robot. The adaptive control agent consists of two neural network units, known as actor and critic for learning prediction and learning control tasks. Results of the presented control method reveal its efficiency in stable walking control of the biped robot model as a nonlinear complex dynamic task.Index Terms-Adaptive control, biped robot, neural network reinforcement learning,stable walking.
The Lotka-Volterra or predator-prey models contain a pair of first order, non-linear, differential equations, which describe the dynamics of two species interaction in biological systems. Hence, accurate simulation strategies development for mentioned equations is crucial. In this paper, first, the presented model equations are simulated by ARX, ARMAX and BJ parametric models of the Identification Toolbox in MATLAB software. Afterwards, this simulation has been done in the Neural Network Toolbox by Feed-Forward and Elman networks with equal number of neurons, layers and same transfer functions. Finally, the results of these two simulations have been compared to introduce the best simulation methodology. It is shown that more accurate results are achieved by Elman network. In addition, the paper demonstrates that the simulation error can be decreased by simply increasing the number of these neural networks’ neurons.
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