An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations.

Purpose China’s rapid pace of urbanization has resulted in millions of rural residents migrating from rural areas to urban areas for better job opportunities. Due to economic pressures and the nature of China’s demographic policies, many of these migrants have been forced to leave their children with relatives – typically paternal grandparents – at home in the countryside. Thus, while income for most migrant families has risen, a major unintended consequence of this labor movement has been the emergence of a potentially vulnerable sub-population of left-behind children (LBCs). The purpose of this paper is to examine the impacts of parental migration on both the academic performance and mental health of LBCs. Design/methodology/approach Longitudinal data were drawn from three waves of a panel survey that followed the same students and their families – including their migration behavior (i.e. whether both parents, one parent, no parent migrated) – between 2015 and 2016. The survey covers more than 33,000 students in one province of central China. The authors apply a student fixed-effects model that controls for both observable and unobservable confounding variables to explicate the causal effects of parental migration on the academic and mental health outcomes for LBC. The authors also employ these methods to test whether these effects differ by the type of migration or by gender of the child. Findings The authors found no overall impact of parental migration on either academic performance or mental health of LBCs, regardless of the type of migration behavior. The authors did find, however, that when the authors examined heterogeneous effects by gender (which was possible due to the large sample size), parental migration resulted in significantly higher anxiety levels for left-behind girls. The results suggest that parental migration affects left-behind boys and girls differently and that policymakers should take a more tailored approach to addressing the problems faced by LBCs. Originality/value The main contributions of this paper come from the large and representative sample, as well as the causal effects analysis of being left-behind on both academic performance and mental health. First, the paper uses comprehensive panel data from a representative and populous province in China, and the sample size is the largest one among LBC-related papers to the authors’ knowledge. Second, the paper separately examines the causal effects on the student outcomes of different migration strategies. Third, the paper analyzes the heterogeneous effects of different migration strategies on LBC gender. The authors believe that the paper makes a key contribution to the literature.

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Shuttle Radar Topography Mission (SRTM) digital elevation model (DEM) inherently suffers from various errors. Many previous works employed Geoscience Laser Altimeter System onboard the Ice, Cloud, and land Elevation Satellite (ICESat/GLAS) data to assess and enhance SRTM DEM accuracy. Nevertheless, data coregistration between the two datasets was commonly neglected in their studies. In this paper, an automated and simple three dimensional (3D) coregistration method (3CM) was introduced to align the 3-arc-second SRTM (SRTM3) DEM and ICESat/GLAS data over Jiangxi province, China. Then, accuracy evaluation of the SRTM3 DEM using ICESat/GLAS data with and without data coregistration was performed on different classes of terrain factors and different land uses, with the purpose of evaluating the importance of data coregistration. Results show that after data coregistration, the root mean square error (RMSE) and mean bias of the SRTM3 DEM are reduced by 14.4% and 97.1%, respectively. Without data coregistration, terrain aspects with a sine-like shape are strongly related to SRTM3 DEM errors; nevertheless, this relationship disappears after data coregistration. Among the six land uses, SRTM3 DEM produces the lowest accuracy in forest areas. Finally, by incorporating land uses, terrain factors and ICESat/GLAS data into the correction models, the SRTM3 DEM was enhanced using multiple linear regression (MLR), back propagation neural network (BPNN), generalized regression NN (GRNN), and random forest (RF), respectively. Results exhibit that the four enhancement models with data coregistration obviously outperform themselves without the coregistration. Among the four models, RF produces the best result, and its RMSE is about 3.1%, 2.7% and 11.3% lower than those of MLR, BPNN, and GRNN, respectively. Moreover, 146 Global Navigation Satellite System (GNSS) points over Ganzhou city of Jiangxi province were used to assess the accuracy of the RF-derived SRTM3 DEM. It is found that the DEM quality is improved and has a similar error magnitude to that relative to the ICESat/GLASS data.

The degradation of water environment (WE) has constrained the sustainable development of cities, while the rapid urbanization also exacerbates water environment change. However, the complicated relationship between urbanization and WE is far from clearly understood. In this study, a comprehensive index system for urbanization and WE was applied along with the System Index Evaluation Model (SIEM) and a Coupling Coordination Degree Model (CCDM) to analyze the coupling between urbanization and WE in Nanjing, East China, from 1990 to 2018. The comprehensive index of urbanization increased from 0.0392 in 1990 to 0.9890 in 2018, showing a clear increasing trend. Demographic and spatial urbanization made the largest contribution to urbanization development from 1990 to 2010, while economic urbanization became the largest contributor to urbanization development between 2011 and 2018. Under the combined effects of pressure, state, and response subsystems, the comprehensive WE index showed an upward trend with some fluctuations from 1990 to 2018. The degree of coupling coordination between urbanization and WE displayed an overall upward tendency, growing from 0.18 in 1990 to 0.95 in 2018. The coupling coordination state transitioned from a serious imbalance during the low coupling period (1990–1992) into the superior coordination of the highly coupled period (2011–2018). With the continuous urbanization in the future, in addition to ensuring the optimal management of surface water, protection of groundwater should be reinforced. The results advance our understanding of the dynamic relationship between urbanization and WE and provide important implications for urban planning and water resource protection.

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Aim: The aim of this study was to evaluate the reporting quality of chronic kidney disease (CKD) guidelines. Methods: PubMed, EMBASE, and guideline-related websites were searched from 2008 to 2019. The CKD guidelines were included. Two reviewers used the RIGHT (Reporting Items for Practice Guidelines in Healthcare) checklist to assess the quality of guidelines and calculate the reporting proportion of each guideline. Results: We included 13 guidelines, of which 30.8% (4/13) were developed in Europe and about two-thirds (8/13) were published on their own website. The average quality of the 13 guidelines was 68.57%. The reporting proportion of the seven domains (i.e. basic information; background; evidence; recommendations; review and quality assurance; funding and declaration and management of interests; other information) were 65.39%, 81.73%, 63.08%, 69.23%, 53.85%, 63.46%, and 61.54%, respectively. Conclusion: CKD guidelines had moderate reporting quality in some domains, but guideline developers should increase the reporting items in basic information, guideline evidence, and recommendations. The RIGHT checklist would be a useful tool to improve the reporting quality of guidelines.