Periodontitis is a common infectious disease. Recent studies have indicated that the progression of periodontitis may be regulated by interactions between host immunity and periodontopathic bacteria. Although periodontopathic bacteria can destroy periodontal tissue, a dysfunctional host immune response triggered by the bacteria can lead to more severe and persistent destruction. Toll-like receptors (TLRs), a type of pattern recognition receptor (PRR) that recognizes pathogens, have been implicated in host innate immune responses to periodontopathic bacteria and in the activation of adaptive immunity. TLR-targeted drugs may hold promise to treat periodontal disease. This review summarizes recent studies on the role of TLRs in periodontitis and discusses areas needing further research. We believe TLRs may be an effective biomarker for the prevention, diagnosis, and treatment of periodontitis in the near future.

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Oxymatrine (OMT), a monosomic alkaloid extracted from the Chinese herb, Sophora flavescens Ait, has long been used as a traditional Chinese medicine for the treatment of inflammatory diseases. The aim of the present study was to investigate the potential anti-inflammatory effect of OMT, and its modulation on imbalance between regulatory T (Treg) cells and T helper (Th) 17 cells in rats with collagen-induced arthritis (CIA). Sprague-Dawley rats were immunized with type II collagen and following a second collagen immunization, the rats were treated with OMT or dexamethasone (DXM) intraperitoneally once a day for 43 days. Paw swelling, arthritic score and joint histopathology were evaluated. The Treg/Th17-mediated autoreactive response was assessed by determining serum levels of inflammatory response cytokines, including tumor necrosis factor (TNF)-α and interleukin (IL)-17, using an enzyme-linked immunosorbent assay. The mRNA levels of forkhead box P3 (FOXP3) and retinoic acid-related orphan receptor (ROR)γt in spleen cells stimulated with type II collagen were determined using reverse transcription-quantitative polymerase chain reaction analysis. In addition, the protein expression levels of FOXP3 and RORγt were measured using western blot analysis. The results showed that OMT treatment significantly reduced the severity of CIA, markedly abrogating paw swelling, arthritic scores and synovial hyperplasia, and the increased loss in body weight. OMT significantly reduced the production of TNF-α and IL-17A, upregulated FOXP3 and downregulated RORγt in rats with CIA. In conclusion, the present study demonstrated that OMT exhibited a protective effect on rheumatoid arthritis (RA) through the inhibition of inflammation and regulation of Treg/Th17 in the CIA rats, suggesting that OMT may be used as an immune suppressive and cartilage protective medicine in human RA.

The vascular system, which transports oxygen and nutrients, plays an important role in wound healing, cardiovascular disease treatment and bone tissue engineering. Angiogenesis is a complex and delicate regulatory process. Vascular cells, the extracellular matrix (ECM) and angiogenic factors are indispensable in the promotion of lumen formation and vascular maturation to support blood flow. However, the addition of growth factors or proteins involved in proangiogenic effects is not effective for regulating angiogenesis in different microenvironments. The construction of biomaterial scaffolds to achieve optimal growth conditions and earlier vascularization is undoubtedly one of the most important considerations and major challenges among engineering strategies. Nanomaterials have attracted much attention in biomedical applications due to their structure and unique photoelectric and catalytic properties. Nanomaterials not only serve as carriers that effectively deliver factors such as angiogenesis-related proteins and mRNA but also simulate the nano-topological structure of the primary ECM of blood vessels and stimulate the gene expression of angiogenic effects facilitating angiogenesis. Therefore, the introduction of nanomaterials to promote angiogenesis is a great helpful to the success of tissue regeneration and some ischaemic diseases. This review focuses on the angiogenic effects of nanoscaffolds in different types of tissue regeneration and discusses the influencing factors as well as possible related mechanisms of nanomaterials in endothelial neovascularization. It contributes novel insights into the design and development of novel nanomaterials for vascularization and therapeutic applications.

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Thermoluminescence (TL) characteristics and dosimetric properties of Ba2Ca(BO3)2 phosphor doped with Tb3+ exposed to gamma‐ray irradiation are reported for the first time. Firstly, the influence of different rare earth dopants, i.e. Dy3+, Tb3+ and Tm3+, on TL of Ba2Ca(BO3)2 phosphor is discussed. All glow curves consist of two TL peaks located at 109–120 °C and 199–220 °C and Tb3+‐doped Ba2Ca(BO3)2 phosphor exhibits the highest TL sensitivity. Secondly, the effects of concentration of Tb3+ and gamma‐ray irradiation dose on TL are investigated. The optimum Tb3+ concentration is 2 mol% and the TL kinetic parameters of Ba2Ca(BO3)2:0.02Tb are calculated by the peak shape method. The high‐temperature peak for this sample shifts to higher temperature with increasing irradiation dose. Furthermore, the dosimetric properties of Ba2Ca(BO3)2:0.02Tb phosphor, i.e. the pre‐irradiation annealing treatment, reproducibility and linearity, are studied, the results of which indicate that Tb3+‐doped Ba2Ca(BO3)2 phosphor has a potential application in the personal protection dosimetry field. TL emission of the phosphor is observed to peak at about 485, 542, 580 and 625 nm originating from the characteristic transitions of Tb3+. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Purpose By using a nontraditional configuration approach, the purpose of this paper is to examine the effect of personality on entrepreneurial intention and success. Previous research has focused on why individuals become entrepreneurs and why some are more successful than others. However, most studies have investigated only single factors or primary personality traits. The current study investigates not only the strength of the personality-entrepreneurship link, but also clarifies the nature of the relationship. Design/methodology/approach Using two independent samples and an innovative regression-based pattern recognition procedure, the study investigates whether the nature of the personality-entrepreneurship relationship is driven by individuals’ absolute trait levels or by their idiosyncratic configuration of personality traits. The non-entrepreneur sample consisted of 225 business students in Eastern China, specializing in a variety of business subjects. The entrepreneur sample consisted of 120 business owners in a university entrepreneurial park in Eastern China. Findings Results support hypotheses that the two different types of entrepreneurship criteria are predicted by different personality profile effects. Entrepreneurial intentions are driven by individuals’ personality patterns (peaks and valleys in profiles). In contrast, entrepreneurial success is driven by personality levels (individuals’ relative standing on personality traits compared to other entrepreneurs). Research limitations/implications The findings enrich the understanding of entrepreneurial personality. The more significant contribution of the present study was that it differentiated between personality profile pattern and level effects and investigated whether the nature of the personality-entrepreneurship relationship is driven by individuals’ absolute trait levels (i.e. how high or low they score compared to others), or by their idiosyncratic configuration of personality traits (i.e. their strengths and weaknesses). Practical implications The findings of this study may help entrepreneurs to figure out how to be successful running their own businesses, if they are not graced with a personality pattern that is not favorable to entrepreneurship. In addition, these findings can help entrepreneurship educators to understand how best to train entrepreneurs. Originality/value The adoption of both person-centered approach and process perspective of entrepreneurship allowed this study to make major contributions to entrepreneurial personality research.