Azobenzene-containing polymers (azopolymers) can serve as building blocks for an emerging class of soft photonics. Using their photoresponses for the micro/nanofabrication of smart surface is a key but still a challenging step. Here, we report a simple visible-light-illumination strategy to trigger diverse configurations of surface wrinkling on azopolymer-based film/substrate systems, which can be switched between flat and wrinkled states by controlling the intensity of the incident light. Different photoresponsive characteristics of azobenzene are involved in driving the wrinkling/dewrinkling switch. For the first time, we achieve the controlled wrinkling with an unexpected high aspect ratio and surprisingly polarization-independent ordered orientation by exploiting the unique photosoftening effect of azobenzene. Theoretical analysis reveals that an in situ photoinduced reversible soft/hard-contrast boundary determines the wrinkling orientation, which is used to fabricate diverse on-demand hierarchical wrinkles. These photoresponsive systems find broad photonic applications that are not easily accessible to other systems, e.g., optically reversible smart display, information security, and well-regulated optical devices.

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Rationale:Hypereosinophilic syndrome (HES) is a rare disease characterized by hypereosinophilia and its ensuing organ damage. Cardiac involvement is divided into 3 chronological stages: an acute necrotic stage; a thrombus formation stage; and a fibrotic stage. Infiltration of the myocardium by eosinophilic cells followed by endomyocardial fibrosis is known as “Loeffler endocarditis.”Patient concerns:We report a case of a 60-year-old man diagnosed with left-sided restrictive cardiomyopathy.Diagnosis:The patient experienced heart failure with preserved ejection fraction. The cardiac MRI showed intense, linear, delayed gadolinium enhancement of the endocardium of the lateral wall of the left ventricle, and obliteration of the LV apex. He was ultimately identified as Loeffler endocarditis.Intervention:A bone marrow smear and biopsy revealed the FIP1L1-PDGFRA fusion gene was positive in 82% of segmented nucleated cells.Outcome:Our patient responded well to prednisone at 1 mg/kg/d.Lessons:HES is a rare disease that often afflicts the heart. Cardiac involvement in hypereosinophilia, especially Loeffler endocarditis, carries a poor prognosis and significant mortality. Early detection and treatment of the disease is therefore essential. Further studies are needed to ascertain therapeutic corticosteroid dosages and develop targeted gene therapies, both important steps to ameliorate the effects of Loeffler endocarditis and improve patient outcomes.

Purpose: Stray radiation exposures are of concern for patients receiving proton radiotherapy and vary strongly with several treatment factors such as proton energy, field size and modulation width. The purposes of this study were to conservatively estimate neutron exposures for a contemporary passive scattering proton treatment unit and to understand how they vary with treatment factors. Method and Materials: We simulated all 24 options (each range modulator and second scatterer combination is accounted for one option) for a passive scattering proton therapy unit with MCNPX. Spectral neutron fluence from simulations was then converted to neutron dose equivalent using corresponding dose conversion factors. We studied the neutron dose equivalent per therapeutic absorbed dose (H/D) as a function of treatment factors including proton energy, location in the treatment room, treatment field size, and spread‐out Bragg peak (SOBP) width using Monte Carlo simulation. Results: The H/D value at isocenter for a 250‐MeV medium field size option was estimated to be 20 mSv Gy−1. H/D decreased to about 20% from 250 Mev to 160 MeV. H/D fell off sharply with distance from the treatment unit, approximately following a power law; H/D was about 10% higher for a large field option than a medium field option for the same energy. H//D almost doubled when SOBP width was increased from a pristine peak to 16 cm. An analytical model was developed, which predicted H/D values within 28% of those obtained in simulations; this value is within typical neutron measurement uncertainties. Conclusion: The results quantified how treatment factors influence H/D values. The in‐air method with a closed aperture presented here provides a simple and straightforward approach that could be adopted for facility inter‐comparisons. In addition, an analytical model was developed to quickly estimate H/D values.

effects in transversely isotropic materials-I: Theoretical analysis, simulations and inverse method, Journal of the Mechanics and Physics of Solids, http://dx.Abstract A body force concentrated at a point and moving at a high speed can induce shear-wave Mach cones in dusty-plasma crystals or soft materials, as observed experimentally and named the elastic Cherenkov effect (ECE). The ECE in soft materials forms the basis of the supersonic shear imaging (SSI) technique, an ultrasound-based dynamic elastography method applied in clinics in recent years.Previous studies on the ECE in soft materials have focused on isotropic material models. In this paper, we investigate the existence and key features of the ECE in anisotropic soft media, by using both theoretical analysis and finite element (FE) simulations, and we apply the results to the non-invasive and non-destructive characterization of biological soft tissues. We also theoretically study the characteristics of the shear waves induced in a deformed hyperelastic anisotropic soft  We show that a shear source moving through an incompressible transversely isotropic soft material with a speed greater than the propagation velocity of the shear wave induced in soft media will create elastic Cherenkov effects. Moreover, when the moving speed of the shear source is high, the angle of the Mach cone is small, and quasi-plane waves are generated 2 material by a source moving with high speed, considering that contact between the ultrasound probe and the soft tissue may lead to finite deformation. On the basis of our theoretical analysis and numerical simulations, we propose an inverse approach to infer both the anisotropic and hyperelastic parameters of incompressible transversely isotropic (TI) soft materials. Finally, we investigate the properties of the solutions to the inverse problem by deriving the condition numbers in analytical form and performing numerical experiments. In Part II of the paper, both ex vivo and in vivo experiments are conducted to demonstrate the applicability of the inverse method in practical use.

Compression of a film/substrate bilayer system with different surface/interfacial structures can lead to diverse buckling patterns including sinusoidal wrinkles, ridges, folds, creases and tilted sawteeth wrinkles. In this paper, we show that elastic wave band gaps in the film/substrate bilayer system largely depend on the wrinkling patterns. More interestingly, we find that different wrinkling patterns investigated here can coexist and evolve in one bilayer system and the elastic wave propagation behaviors can be controlled by manipulating the hybrid wrinkling patterns. Our analysis also reveals that the periodic stress pattern plays a dominant role in tuning the bandgap structures in comparison to geometrical patterns caused by surface instability. A careful investigation of the transmission spectra of the composite systems has validated the main findings given by the analysis based on the Bloch wave theory. Potential use of the method and materials reported here to gain wide attenuation frequency ranges and the design of nesting Fibonacci superlattices have been demonstrated.

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