Our study supports the original FDA label with regard to the dosing regimen of gentamicin in ESRD patients, which offers adequate clinical benefit as well as an acceptable safety profile.
Using downhole annular electromagnetic flow measurement to obtain annular flow in real-time is a foundation of microflow control drilling technology. The existing annular flow electromagnetic measurement method based on low-frequency rectangular excitation is affected by slurry interference and formation fluid invasion, which results in large noise generated on the electrode output signal. These noise causes the instability of the flow measurement system output and lower accuracy. Double-frequency rectangular wave excitation has the advantages of excellent zero-point stability attributed to low-frequency rectangular wave excitation and fast response speed with great ability to suppress slurry interference. First, the double-frequency rectangular wave excitation for annular flow electromagnetic measurement is researched, and its corresponding electromagnetic induction signal process is investigated. In order to verify the feasibility of downhole annular electromagnetic flow measurement, a flow verification platform for comparison of standard and detected parameters is established for simulation experiment, and the ability to suppress slurry interference and response speed of the technology in downhole slurry flow measurement are analyzed. The test results show that the downhole annular electromagnetic flow measurement based on double-frequency rectangular wave excitation can not only satisfy the requirements of regular electromagnetic flow measurement but also suppress the annular slurry interference effectively.
Pogostemon cablin (Blanco) Benth. is an important medicinal plant in Traditional Chinese Medicine (TCM). Because of differences in the chemical composition, this species has been classified into two major chemotypes, i. e. the patchouliol-type and the pogostone-type; however, no quick and effective method is presently available for the precise identification of these two chemotypes. DNA barcoding, using a standardized DNA fragment, is a promising molecular diagnostic method for species identification. We have established a reliable and quick method for the identification of the P. cablin chemotypes. Of five potential barcodes [rbcL, psbA-trnH, rpoB, ITS (internal transcibed spacer), and ndhJ], tested among 103 samples, ITS was the best candidate, as comparative studies between patchouliol-type and pogostone-type P. cablin revealed that ITS had more variable regions among these five barcodes. We suggest that ITS can serve as the most suitable barcode for differentiating between the chemotypes of P. cablin
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.