Clinical Study on Food Safety evaluation of Panax ginseng

Kim, Donghwi; Xu, Yanhua; Kim, Young Chang; Bang, Kyong-Hwan; Kim, Jang Uk; Woo, Seon Rang; He, Zhong Mei; He, Yang; Jang, In Bok; Zhang, Lian Xue

doi:10.7783/kjmcs.2015.23.3.185

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Thus, further research is needed to evaluate the effect of vitamin D on COVID-19 vaccination. Additionally, based on the results of several clinical trials for the safety of KRG in healthy Korean adults [ 13 , 41 , 57 ], the safety of taking 3 g KRG per day for four weeks in our study was validated.…”

Section: Discussionmentioning

confidence: 99%

Korean Red Ginseng Potentially Improves Maintaining Antibodies after COVID-19 Vaccination: A 24-Week Longitudinal Study

et al. 2023

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Despite the effectiveness and safety of COVID-19 vaccines, vaccine-induced responses decline over time; thus, booster vaccines have been approved globally. In addition, interest in natural compounds capable of improving host immunity has increased. This study aimed to examine the effect of Korean Red Ginseng (KRG) on virus-specific antibodies after COVID-19 vaccination. We conducted a 24 week clinical pilot study of 350 healthy subjects who received two doses of the COVID-19 vaccine and a booster vaccination (third dose). These subjects were randomized 1:2 to the KRG and control groups. We evaluated antibody response five times: just before the second dose (baseline), 2 weeks, 4 weeks, 12 weeks after the second dose, and 4 weeks after the third dose. The primary endpoints were changes in COVID-19 spike antibody titers and neutralizing antibody titers. The antibody formation rate of the KRG group was sustained higher than that of the control group for 12 weeks after the second dose. This trend was prominently observed in those above 50 years old. We found that KRG can help to increase and maintain vaccine response, highlighting that KRG could potentially be used as an immunomodulator with COVID-19 vaccines.

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Section: Discussionmentioning

confidence: 99%

Korean Red Ginseng Potentially Improves Maintaining Antibodies after COVID-19 Vaccination: A 24-Week Longitudinal Study

et al. 2023

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“…With respect to cases in which red ginseng increased body heat (the sense of heat caused by an increase in qi ) in Chinese subjects, according to the results of research on safety following the intake of red ginseng, white ginseng, or American ginseng by South Korean and Chinese individuals, there were no differences in general symptoms or adverse events by ginseng type or subject nationality [124] . After taking 3 g/day of white ginseng, red ginseng, or American ginseng for 35 days, healthy individuals were proven by the results of blood and biochemical tests to be unaffected and did not experience any adverse event [134] . It has been reported that, after menopausal women took ginseng, breast pain increased in seven cases and vaginal bleeding and sexual desire increased in one case [8] .…”

Section: Safety/adverse Eventsmentioning

confidence: 99%

Red ginseng monograph

Lee

Kim

et al. 2018

Journal of Ginseng Research

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Ginseng has been traditionally used for several millennia in Asian countries, including Korea, China, and Japan, not only as a nourishing and tonifying agent but also as a therapeutic agent for a variety of diseases. In recent years, the various effects of red ginseng including immunity improvement, fatigue relief, memory improvement, blood circulation improvement, antioxidation, mitigation of menopausal women's symptoms, and anticancer an effect have been reported in clinical as well as basic research. Around the world, there is a trend of the rising consumption of health functional foods on the level of disease prevention along with increased interest in maintaining health because of population aging and the awareness of lifestyle diseases and chronic diseases. Red ginseng occupies an important position as a health functional food. But till now, international ginseng monographs including those of the World Health Organization have been based on data on white ginseng and have mentioned red ginseng only partly. Therefore, the red ginseng monograph is needed for component of red ginseng, functionality certified as a health functional food in the Korea Food and Drug Administration, major efficacy, action mechanism, and safety. The present red ginseng monograph will contribute to providing accurate information on red ginseng to agencies, businesses, and consumers both in South Korea and abroad.

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