CEUS could accurately assess renal microvascular perfusion in a real-time and dynamic manner. PI, TTP and AUC could be used for the diagnosis of the renal microvascular damage in early and late stage diabetic patients. CEUS is a safe, noninvasive and simple technique to detect the severity of kidney microvascular perfusion deficits.
Abstract:In this article, we conducted the evaluation of artificial intelligence research from 1990-2014 by using bibliometric analysis. We introduced spatial analysis and social network analysis as geographic information retrieval methods for spatially-explicit bibliometric analysis. This study is based on the analysis of data obtained from database of the Science Citation Index Expanded (SCI-Expanded) and Conference Proceedings Citation Index-Science (CPCI-S). Our results revealed scientific outputs, subject categories and main journals, author productivity and geographic distribution, international productivity and collaboration, and hot issues and research trends. The growth of article outputs in artificial intelligence research has exploded since the 1990s, along with increasing collaboration, reference, and citations. Computer science and engineering were the most frequently-used subject categories in artificial intelligence studies. The top twenty productive authors are distributed in countries with a high investment of research and development. The United States has the highest number of top research institutions in artificial intelligence, producing most single-country and collaborative articles. Although there is more and more collaboration among institutions, cooperation, especially international ones, are not highly prevalent in artificial intelligence research as expected. The keyword analysis revealed interesting research preferences, confirmed that methods, models, and application are in the central position of artificial intelligence. Further, we found interesting related keywords with high co-occurrence frequencies, which have helped identify new models and application areas in recent years. Bibliometric analysis results from our study will greatly facilitate the understanding of the progress and trends in artificial intelligence, in particular, for those researchers interested in domain-specific AI-driven problem-solving. This will be of great assistance for the applications of AI in alternative fields in general and geographic information science, in particular.
Gout and hyperuricemia are highly prevalent metabolic diseases caused by high level of uric acid. Amino acids (AAs) involve in various biochemical processes including the biosynthesis of uric acid. However, the role of AAs in discriminating gout from hyperuricemia remains unknown. Here, we report that the plasma AAs profile can distinguish acute gout (AG) from asymptomatic hyperuricemia (AHU). We established an LC-MS/MS-based method to measure the plasma AAs without derivatization for the AG and AHU patients, and healthy controls. We found that the plasma profiling of AAs separated the AG patients from AHU patients and controls visually in both principal component analysis and orthogonal partial least-squares discriminant analysis (OPLS-DA) models. In addition, L-isoleucine, L-lysine, and L-alanine were suggested as the key mediators to distinguish the AG patients from AHU and control groups based on the S-plot analysis and variable importance in the projection values in the OPLS-DA models, volcano plot, and the receiver operating characteristic curves. In addition, the saturation of monosodium urate in the AA solutions at physiologically mimic status supported the changes in plasma AAs facilitating the precipitation of monosodium urate. This study suggests that L-isoleucine, L-lysine, and L-alanine could be the potential markers to distinguish the AG from AHU when the patients have similar blood levels of uric acid, providing new strategies for the prevention, treatment, and management of acute gout.
Benzbromarone and febuxostat could reduce SUA and maintain renal function in chronic kidney disease (CKD) patients with eGFR 20-60 mL/min/1.73 m. Urate-lowering therapy with benzbromarone or febuxostat could increase serum hemoglobin level and potentially improve anemia.
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