A 26-year-old male presented with a pain over the lateral aspect of the right ankle and heel of 6 months' duration. Radiographs of the right foot revealed an apparent multilocular unicamelar bone cyst. Computed tomography scans revealed an eccentric lytic lesion. On Tl-weighted images of magnetic resonance imaging, the bone lesion appeared as a low-to-intermediate intensity mass. On T2-weighted images, cystic lesion appeared as a mass of high intensity. These images were extremely informative and were important in planning the surgical treatment. The patient underwent excision and curettage and bone grafting of the lesion. Histologically, giant cell tumor of calcaneus was diagnosed, but the large amount of serosanguineous fluid and the acellular cavernous calcaneus suggested an aneurysmal bone cyst was also present. The clinical presentations of giant cell tumor of bone and aneurysmal bone cyst are similar. Thus the clinical presentation, anatomical location, radiographic findings and histologic appearance provide the basis for diagnosis and treatment.
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