Aneurysmal bone cyst arising from a giant cell tumor of the calcaneus

Jf, Yale; Ja, Kaplan

doi:10.7547/87507315-85-11-708

Cited by 6 publications

(3 citation statements)

References 4 publications

(5 reference statements)

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“…GCT may occur in the skull or pelvis secondary to Paget disease (9). The bones of the hands and feet are uncommon locations (Fig 6), with a prevalence of less than 2% (15)(16)(17). Multicentric GCT has been reported in less than 1% of cases, with lesions often located in the distal extremities, particularly the hands and feet (18)(19)(20)(21).…”

Section: Uncommon Radiologic Manifestationsmentioning

confidence: 99%

Giant Cell Tumor of Bone: Review, Mimics, and New Developments in Treatment

Chakarun

Forrester²,

Gottsegen³

et al. 2013

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Giant cell tumor (GCT) of bone is generally a benign tumor composed of mononuclear stromal cells and characteristic multinucleated giant cells that exhibit osteoclastic activity. It usually develops in long bones but can occur in unusual locations. The typical appearance is a lytic lesion with a well-defined but nonsclerotic margin that is eccentric in location, extends near the articular surface, and occurs in patients with closed physes. However, GCT may have aggressive features, including cortical expansion or destruction with a soft-tissue component. Fluid-fluid levels, consistent with secondary formation of aneurysmal bone cysts, are seen in 14% of cases. GCT can mimic or be mimicked by other benign or malignant lesions at both radiologic evaluation and histologic analysis. Rarely, GCT is associated with histologically benign lung metastases or undergoes malignant degeneration. In the past, the mainstay of treatment was surgical, primarily consisting of curettage with cement placement, with recurrence rates of 15%-25%. Recurrence is suggested by development of progressive lucency at the cement-bone interface. Other complications include pathologic fracture and postoperative infection. Denosumab, a monoclonal antibody that targets the osteoclastic activity of GCT, has produced 90% tumor necrosis in early studies, results indicative of promise as a potential adjuvant therapy.

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Section: Uncommon Radiologic Manifestationsmentioning

confidence: 99%

Giant Cell Tumor of Bone: Review, Mimics, and New Developments in Treatment

Chakarun

Forrester²,

Gottsegen³

et al. 2013

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330

348

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“…However, aggressive features may additionally be identified, including cortical expansion or destruction of the soft tissue component ( 65 ). MRI reveals low signal intensity on the T1-weighted image and a high signal intensity on the T2-weighted image ( 69 ). The histological features consist of numerous multinucleated giant cells.…”

Section: Benign Calcaneal Tumour Typesmentioning

confidence: 99%

“…The histological features consist of numerous multinucleated giant cells. Spindle cells and ABC features may be present in certain areas ( 65 , 69 ).…”

Section: Benign Calcaneal Tumour Typesmentioning

confidence: 99%

Primary tumours of the calcaneus (Review)

et al. 2018

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The calcaneus is a rare location for the occurrence and development of primary tumour types. Clinicians are unfamiliar with calcaneal tumour types, which may result in a delay in diagnosis or a missed diagnosis, resulting in unnecessary morbidity and amputation. Heel pain and localized swelling of the ankle are the most common symptoms. X-ray is the first choice for a tentative diagnosis of a calcaneal tumour. The final diagnosis depends on a histological examination. The treatment of calcaneal tumour types varies depending on the Enneking system. The majority of patients with benign tumours heal, except for a few with a palindromia. For malignant tumours, the prognosis is comparatively poor, resulting in disability and a high rate of metastasis. This review describes the spectrum of calcaneal tumour types and specifically illustrates the epidemiology, symptomatology, imagology, histopathology and treatment options that may facilitate diagnosis and improve prognosis.

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Xanthoma of a calcaneus

Kinberg¹

1998

The Journal of Foot and Ankle Surgery

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Aneurysmal bone cyst arising from a giant cell tumor of the calcaneus

Cited by 6 publications

References 4 publications

Giant Cell Tumor of Bone: Review, Mimics, and New Developments in Treatment

Giant Cell Tumor of Bone: Review, Mimics, and New Developments in Treatment

Primary tumours of the calcaneus (Review)

Xanthoma of a calcaneus

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