HighlightsA variety of associated malignancies can arise from PTs, with its dual population of cells.Heterologous sarcomatous elements usually accompany high grade PTs.The presence of a malignant heterologous component places the “Philloides tumor” into the malignant category regardless of other histological features.
In this study, we aimed to analyze the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in ICU patients diagnosed with sepsis or septic shock.
MethodsThe levels of procalcitonin (PCT) and C-reactive protein (CRP), determined to be indicators of infection/sepsis, and the levels of interleukins (IL-6, IL-8, and IL-10) and tumor necrosis factor α (TNFα), deemed as indicators of the cytokine storm, were compared among 32 patients before and after the hemadsorption procedure.
ResultsThe hemadsorption significantly reduced the levels of IL-6, IL-8, IL-10, TNFα, PCT, CRP, Acute Physiology and Chronic Health Evaluation (APACHE) scores, mortality rate, and Sequential Organ Failure Assessment (SOFA) scores (p<0.05). APACHE scores and the mean predicted mortality rate (PMR) of the non-survivors measured before the procedure was significantly higher than those of survivors (p=0.002 for both). IL-10, APACHE scores, and the mortality rates determined before the hemadsorption procedure were deemed significant parameters to predict the mortality among all ICU patients (p<0.05). IL-10 levels ≤125.3 ng/L, APACHE score >30, and PMR >70.33 were significantly associated with the mortality rates of all patients, indicating that these three parameters determined before the hemadsorption may be good predictors of mortality among ICU patients with sepsis.
ConclusionThe progression of sepsis in ICU patients may be prevented with cytokine hemadsorption applied as an immunomodulator therapy.
Ductal papillomas are rarely seen in salivary glands. They are largely classified under the term "ductal papillomas" and generally further categorized as intraductal papilloma, sialadenoma papilliferum, and inverted ductal papilloma. Intraductal papilloma, which usually arises from the major lactiferous duct and localized in minor salivary glands, is an uncommon lesion. We report a case of intraductal papilloma of the buccal mucosa.
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