The
growing population of peri-implant diseases (PIDs) has become
a public obsession, mainly due to the lack of antibacterial ability
and osteogenic promotion of titanium (Ti) implants. Herein, inspired
by tremella, we reported zinc oxide (ZnO)@collagen type I (Col-I)-decorated
Ti for PIDs treatments. Compared with pure Ti implants, ZnO@Col-I-decorated
Ti could be activated by a safe visible yellow light and showed excellent
broad-spectrum antibacterial properties. The proliferation and osteogenic
gene expression of bone marrow mesenchymal stem cells (BMSCs) indicated
that the triple osseointegration of implants was realized through
(I) the remarkedly improved surface hydrophilicity of ZnO@Col-I-decorated
Ti, (II) the function of Col-I, and (III) the excellent near-infrared
(NIR)-induced photothermal performance of ZnO. Collectively, the proposed
dual-light-defined ZnO@Col-I coating was a promising implant surface
modification system to provide customized treatments for each PID
patient.
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