Objective: Neurodegenerative diseases are defined by irreversible neuronal and glial loss in the central nervous system. Despite sharing neural cell loss as a common denominator, they differ in their clinical manifestations in many aspects. We aimed to analyze the behavioral changes and underlying immunohistochemical changes in mice caused by an environmental stressor, l-methionine, to assess the spectrum of clinical findings observed in these diseases. Material and Method: In this study, the mice are divided into 4 groups: female-control (n=13), female-methionine (n=12), male-control (n=12), male-methionine (n=13) to perform immunohistochemical and behavioral tests. Starting from post-natal week 6, the mice were either administered water or 8.2g/kg l-methionine for 12 weeks. Consequently, they underwent a series of behavioral tests to assess anxiety, depression, memory/learning, and motor functions. We performed immunohistochemical analysis on mice (3 randomly chosen mice from each group prior to behavior tests) which did not undergo behavioral tests. Results: Compared to the control group, mice who received l-methionine were found to have significant hippocampus dependent spatial memory deficits. No significant differences were found in regards to anxiety and depression. Our immunohistochemical analysis showed a significantly increased senescent astrocyte to all astrocyte ratio in dentate gyrus of hippocampal formation. Conclusion: Chronic administration of an oral high dose of l-methionine results in hippocampus dependent memory decline in mice. Parallel to this finding, the ratio of senescent astrocytes to all astrocytes increased in dentate gyrus.
Malign asit tedavisinde intraperitoneal catumaxomab kullanımı: 4 olgu Amaç: Malign asit tedavisinde catumaksomab tedavisinin etkinliğinin gösterilmesi Olgular: Malign asit nedeniyle haftada 1 ve daha sık parasentez ihtiyacı olup catumaksomab tedavisi planlanan mide kanserli 4 olguda terapötik parasentezi takiben intraperitoneal port kateteri yoluyla 0., 3., 7. ve 10. günlerde catumaksomab uygulandı. Tedavi sonrası ve öncesi parasentez ihtiyaçları karşılaştırılan hastaların herbirinde bu sıklığın azaldığı görüldü. Sonuç: Malign asiti olan hastaların tedavisinde catumaksomab iyi bir seçenek olabilmektedir ve özellikle bu hastaların yaşam kalitelerinin arttırılması için göz önünde bulundurulması gerekmektedir.
Aim: Isolated hepatitis B core antibodies (aHBc)-only pattern complicates the diagnosis of HBV infections. We evaluated neopterin and sCD14 levels in HBV infections. Methods: aHBc-only (n: 102), healthy control (healthy control group [HCG], n: 100), and chronic hepatitis (CHB) groups (n: 70) were investigated. Competitive and sandwich ELISA were used. Results: The mean neopterin levels were significantly lower in the aHBc-only group than those in the CHB group (p = 0.0001). No significant difference was found between the aHBc-only group and the HCG (p = 0.854). The mean sCD14 levels were lower in the aHBc-only group than those in the CHB group (p = 0.0001), but no significant difference was found between the aHBc-only group and HCG (p = 0.402). No significant difference was detected between aHBc-only and HCG for mean sCD14 (p = 0.402) and neopterin levels (p = 0.854). Conclusion: These two biomarkers are not useful for diagnosing the aHBc only pattern.
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