BackgroundEarly identification of response to neoadjuvant chemotherapy (NAC) is instrumental in predicting patients prognosis. However, since a fixed criterion with high accuracy cannot be generalized to molecular subtypes, our study first aimed to redefine grades of clinical response to NAC in invasive breast cancer patients (IBC). And then developed a prognostic model based on clinical features and ultrasound semantics.MethodsA total of 480 IBC patients were enrolled who underwent anthracycline and taxane-based NAC between 2018 and 2020. The decrease rate of the largest diameter was calculated by ultrasound after NAC and their cut-off points were determined among subtypes. Thereafter, a nomogram was constructed based on clinicopathological and ultrasound-related data, and validated using the calibration curve, receiver operating characteristic (ROC) curve, decision curve analysis (DCA), and clinical impact curve (CIC).ResultsThe optimal cut-off points for predicting pCR were 53.23%, 51.56%, 41.89%, and 53.52% in luminal B-like (HER2 negative), luminal B-like (HER2 positive), HER2 positive, and triple-negative, respectively. In addition, time interval, tumor size, molecular subtypes, largest diameter decrease rate, and change of blood perfusion were significantly associated with pCR (all p < 0.05). The prediction model based on the above variables has great predictive power and clinical value.ConclusionTaken together, our data demonstrated that calculated cut-off points of tumor reduction rates could be reliable in predicting pathological response to NAC and developed nomogram predicting prognosis would help tailor systematic regimens with high precision.
The control of Occlusal Vertical Dimension (OVD) 1 is a demanding task for dentists. Establishment of proper occlusal vertical dimension in prosthetic treatment is a important task for clinical procedure.2 No methods are considered to be scientifically accurate in determining the reduced OVD in patients with low occlusal vertical dimension.3 Various factors need to be considered simultaneously during occlusal rehabilitation, such as vertical dimension of occlusion, occlusal contact pattern, centric relation, esthetics and phonetics. Different philosophies have been documented for occlusal rehabilitation and the choice of treatment plan depends on the skills and experience of the dentist. 4 The actual basal bone height of the reconstructed maxillary and mandible is relevant to achieve normal OVD for the prosthesis fabricated.5 This paper described a case with vertical distance problem in which we combined orthodontics with implantation to rehabilitate vertical dimension of occlusion. KEYWORDS:Orthodontic; Implant; Rehabilitate. ABBREVIATIONS:CBCT: Cone-beam computed tomography; OVD: Occlusal Vertical Dimension. TREATMENT STRATEGYA female patient who lost occlusal vertical dimension was treated with this procedure. As shown in Figures 1 and 2, teeth #25, 35, 36, 37, 38 and 46 were diagnosed as residual roots; teeth #16, 26 and 27 were diagnosed as elongation; and teeth #12, 14 and 23 were missing before treatment. The vertical distances between teeth #16, 26 and the mandibular alveolar ridge were only 2 mm respectively when the patient bit together. The distal buccal cusp of tooth #27 almost contacted the mandibular alveolar ridge, as shown in Figures 3 and 4. There was a space of 3 mm between teeth 42 and 43. CBCT images showed low-density shadow around the roots of teeth #11 and 21.
Lymphangiomatosis is a condition of lymphatic tissue malformation with multiple or diffuse involvement of soft tissues, visceral organs. Congenital abnormalities of the lymphatic system are very rare, and reports of congenital lymphangiomatosis are even fewer. We experienced a case of congenital lymphangiomatosis detected as edema of the right limb by prenatal ultrasonography and then diagnosed by magnetic resonance imaging.Supporting information can be found in the online version of this abstract. P28.04Prenatal screen the abnormal flexed direction of knee joints using the parallel moving examination Fuxing Hospital of Capital Medical University, Beijing, ChinaObjectives: To investigate the value of prenatal screen the abnormal flexed direction of knee joints using the parallel moving examination (PME). Methods: Generally, we observe the structure of fetuses, the morphous of limbs, and measure the length of femur. And at the same time, we use parallel moving examination (PME) to observe the fetal flexed direction of knee joint. Results: 4623 fetuses were accepted ultrasound examination. 4586 fetuses were full term delivered, and 37 cases were terminated in second trimester. There were 4617 fetuses' flexed direction of knee joint can be observe satisfactly, 6 cases could not show the flexed direction due to the few amniotic fluid. 3 cases of abnormal flexed direction of knee joints were detected in all fetuses, the incidence rate is 0.06%. 3 fetuses were females and delivered by cesarean section, include 1 case of Larsen syndrome, 2 cases of congenital dislocation of knee joint. The detection rate is 100%. The sensitivity is 100%, the specificity is about 99.98%. Conclusions:The PME ultrasound examination has a high sensitivity. It can show the flexed direction of knee joint, and evaluate the knee joints normal whether or not. PME can enhance the prenatal diagnostic rate of congenital big joints abnormity. Of course, the PME ultrasound examination has locals as general limb ultrasound examination, include the gestational week, amniotic fluid, position of fetus' limbs, and the experience of examiner.Supporting information can be found in the online version of this abstract. Objectives: The diagnosis of skeletal dysplasias by prenatal sonography is limited because in many cases it is only possible during late pregnancy and because the diagnosis of the specific dysplasia is rarely possible. The objective of this study was to evaluate different sonographic signs in fetuses with late diagnosis of limb shortening. Methods: Over a 1 year period, 3 fetuses were observed at our institution at 34-35 weeks' pregnancy with severe shortening of limb bones (femur length 4 to 5 standard deviations below the mean), normal measurements of head and abdomen, and no other anomaly detected by sonography. The postnatal diagnoses were: familiar short stature (FSS); achondroplasia (A) with the classic mutation c. 1138G>A (p. G380R) of the gene FGFR3; and asphyxiating thoracic dystrophy (ATD), causing respiratory insufficiency and death...
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