P28.04: Prenatal screen the abnormal flexed direction of knee joints using the parallel moving examination

Abstract

Lymphangiomatosis is a condition of lymphatic tissue malformation with multiple or diffuse involvement of soft tissues, visceral organs. Congenital abnormalities of the lymphatic system are very rare, and reports of congenital lymphangiomatosis are even fewer. We experienced a case of congenital lymphangiomatosis detected as edema of the right limb by prenatal ultrasonography and then diagnosed by magnetic resonance imaging.Supporting information can be found in the online version of this abstract. P28.04Prenatal screen the abnormal flexed direction of knee joints using the parallel moving examination Fuxing Hospital of Capital Medical University, Beijing, ChinaObjectives: To investigate the value of prenatal screen the abnormal flexed direction of knee joints using the parallel moving examination (PME). Methods: Generally, we observe the structure of fetuses, the morphous of limbs, and measure the length of femur. And at the same time, we use parallel moving examination (PME) to observe the fetal flexed direction of knee joint. Results: 4623 fetuses were accepted ultrasound examination. 4586 fetuses were full term delivered, and 37 cases were terminated in second trimester. There were 4617 fetuses' flexed direction of knee joint can be observe satisfactly, 6 cases could not show the flexed direction due to the few amniotic fluid. 3 cases of abnormal flexed direction of knee joints were detected in all fetuses, the incidence rate is 0.06%. 3 fetuses were females and delivered by cesarean section, include 1 case of Larsen syndrome, 2 cases of congenital dislocation of knee joint. The detection rate is 100%. The sensitivity is 100%, the specificity is about 99.98%. Conclusions:The PME ultrasound examination has a high sensitivity. It can show the flexed direction of knee joint, and evaluate the knee joints normal whether or not. PME can enhance the prenatal diagnostic rate of congenital big joints abnormity. Of course, the PME ultrasound examination has locals as general limb ultrasound examination, include the gestational week, amniotic fluid, position of fetus' limbs, and the experience of examiner.Supporting information can be found in the online version of this abstract. Objectives: The diagnosis of skeletal dysplasias by prenatal sonography is limited because in many cases it is only possible during late pregnancy and because the diagnosis of the specific dysplasia is rarely possible. The objective of this study was to evaluate different sonographic signs in fetuses with late diagnosis of limb shortening. Methods: Over a 1 year period, 3 fetuses were observed at our institution at 34-35 weeks' pregnancy with severe shortening of limb bones (femur length 4 to 5 standard deviations below the mean), normal measurements of head and abdomen, and no other anomaly detected by sonography. The postnatal diagnoses were: familiar short stature (FSS); achondroplasia (A) with the classic mutation c. 1138G>A (p. G380R) of the gene FGFR3; and asphyxiating thoracic dystrophy (ATD), causing respiratory insufficiency and death...