Tomato skins can be a viable source of lycopene. Industrial production of lycopene from tomatoes appears to be in high demand by food companies for the development of functional foods. Majority of companies that are into the business of manufacturing fruit extracts, prefer conventional solvent extraction method. Solvent extraction is extremely efficient with carotenoids (lycopene and β-carotene) with a total of carotenoids recovery of 96%. The optimization of the solvent extraction process for the maximum recovery of lycopene from tomato pomace was carried out by selecting the suitable solvent system, temperature-time combination and feed to solvent ratio, i.e. Acetone: Ethyl acetate (1:1), 40°C/5hr and 1:30 (w/v). The maximum lycopene was extracted using optimized solvent extraction process and had the lycopene content 611.105 mg/100 g, refractive index 1.37604 and colour value 5.59L*, 8.00a*, 6.14b*. The storage of lycopene extract at refrigerated condition was found safe for maintaining its lycopene content. There was just 2.6% reduction in lycopene content after 60 days of storage at refrigerated condition.

New Antihistaminic Agents: Synthesis and Evaluation of H1-Antihistaminic actions of 3-[(N,N-Dialkylamino)alkyl)-1,2,3,4-tetrahydro-(1H)-thioquinazolin-4(3H)-ones and Their oxo Analogues

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Urinary Tract Infections (UTIs) are among the most frequent infectious diseases affecting humans, and represent an important public health problem with a substantial economic burden. Due to the high empiric use of antibiotics for treatment of UTI, antibacterial resistance of Enterobacteriaceae, specifically the main uropathogens Escherichia coli and Klebsiella pneumoniae, has significantly increased worldwide. A retrospective analysis of cases of community acquired UTI reported over last 4 years at Suburban Diagnostics was done. A total of 27,501 cases of UTI were analysed retrospectively. Growth was found in 12,476 (45.36%). 15,025 (54.63%) cases were sterile on culture. Community acquired UTI is showing increasing resistance as seen in our study of 4 years with around 27,000 cases of UTI and around 12,000 isolates. High rates of ESBL-64% of E. coli and 54% Klebsiella isolates found in our study reinforce the fact that this form of resistance is common in community acquired UTI.

Nanosponges (NSs) are minute particles with a size range of about a virus (100-300 nm), which have cavities that can be filled with a hydrophilic or a