Formulation and optimization of carbamazepine floating tablets

Patel, DM; Patel, NM; P, Nn; Ya,; Jogani, PD

doi:10.4103/0250-474x.39430

Cited by 22 publications

(16 citation statements)

References 23 publications

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“…The decrease in floating lag time of the formulations can be referred to the availability of an increased amount of CO2 as the concentration of sodium bicarbonate (NaHCO3 In Formula 11, the floating tablets that prepared with a higher viscosity grade of hydroxypropyl methylcellulose (HPMC) K100M were observed to have increased in floating lag time and total floatation time for more than 24 h in comparison with F10 that prepared with a lower grade of hydroxypropyl methylcellulose (HPMC). This was probably owing to more polymer entanglement and more gel strength also, to the smaller efficacious molecular diffusion area within a high viscosity as compared with a lowviscosity grade of hydroxypropyl methylcellulose (HPMC) [39]. ) was increased, being captured in the formed gel to give buoyancy [38].…”

Section: Floating Behavior Of Tabletsmentioning

confidence: 99%

Formulation and in Vitro Evaluation of Amlodipine Gastroretentive Floating Tablets Using a Combination of Hydrophilic and Hydrophobic Polymers

Alhamdany

Abbas

2018

Int J App Pharm

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Objective: The aim of this study was to formulate a developed floating tablet of amlodipine using different concentrations and types of hydrophilic and hydrophobic polymers to be conserved in the stomach for modulating solubility and bioavailability, diminishes drug waste and decline side effects.Methods: Through this study, eleven innovative formulations of amlodipine floating tablets were prepared [mixture of amlodipine, sodium bicarbonate (NaHCO3), hydroxypropyl methylcellulose (HPMC) E50, HPMC K100M, ethylcellulose (EC) 5 mp. a. s.] by direct compression method. The pre-compressed mixtures were then evaluated for numerous parameters such as angle of repose, bulk density, tapped density, Carr's compressibility index and Hausner's ratio. After compression, tablets were subjected to several tests like; floating behavior of tablets, tablet thickness, hardness test, friability test, weight variation, in vitro dissolution test. In addition, the optimum formulation was evaluated for Fourier transform-infrared (FT-IR) and differential scanning calorimetry (DSC) tests. Results: From in vitro dissolution tests and kinetic assessments; F8 was selected as an optimum formula, depending on the R2 value of zero order kinetics (0.9915) and (n) value of Korsmeyer-Peppas (0.9635) which indicate purely relaxation zero order kinetic with good delaying in drug release that was reached to 14 h.Conclusion: It can be concluded that the developed formulation of a certain combination of low viscosity grades of HPMC and EC was considered an efficient floating tablet.

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Section: Floating Behavior Of Tabletsmentioning

confidence: 99%

Formulation and in Vitro Evaluation of Amlodipine Gastroretentive Floating Tablets Using a Combination of Hydrophilic and Hydrophobic Polymers

Alhamdany

Abbas

2018

Int J App Pharm

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“…The effect of various formulation and process variables were studied. Patel et al 41 formulated and evaluated floating tablets of ranitidine. Two fillers, namely, Avicel PH 102 and Tablettose 80 were used.…”

Section: Work On Gastroretentive Dosage Formmentioning

confidence: 99%

Progress in Controlled Gastroretentive Delivery Systems

Garg¹,

Gupta²

2008

Trop. J. Pharm Res

190

124

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Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. However, the development processes are faced with several physiological difficulties such as the inability to restrain and localize the system within the desired region of the gastrointestinal tract and the highly variable nature of the gastric emptying process. This variability may lead to unpredictable bioavailability and times to achieve peak plasma levels. On the other hand, incorporation of the drug in a controlled release gastroretentive dosage forms (CR-GRDF) which can remain in the gastric region for several hours would significantly prolong the gastric residence time of drugs and improve bioavailability, reduce drug waste, and enhance the solubility of drugs that are less soluble in high pH environment. Gastroretention would also facilitate local drug delivery to the stomach and proximal small intestine. Thus, gastroretention could help to provide greater availability of new products and consequently improved therapeutic activity and substantial benefits to patients. Controlled gastric retention of solid dosage form may be achieved by the mechanisms of floatation, mucoadhesion, sedimentation, expansion or by a modified shaped system. The purpose of this paper is to review the recent literature and current technology used in the development of gastroretentive dosage forms.

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“…Although the regression coefficients of zero-order and Korsmeyer-Peppas model for the three formulations showed relatively low values, all diffusion exponent (n) values, were above 0.5 value, which indicates that the mechanism of drug release from the three formulations follow a non-Fickian release (diffusion and swelling) as expected from hydrophilic polymers like HPMC K4M. [18,19] However, increasing the concentration of HPMC K4M that acts as a release-retarding polymer did not clearly affect the release rates of all three formulations (F2, F3, and F4) which exhibited almost similar release patterns [ Table 5 and Figure 1].…”

Section: Drug Release Kineticsmentioning

confidence: 81%

Untitled

Hamad¹

2018

AJP

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The aim of the study was to prepare and evaluate a gastroretentive sustained release delivery system for doxylamine succinate, using a release-retarding polymer. The floating approach was applied for preparing gastroretentive tablets (GRT). Materials and Methods: Four GRT formulations were prepared by melting granulation technique followed by double compression. The granules were subjected to pre-compression evaluation, namely, angle of repose, loose and tapped bulk densities, Carr's compressibility index, and Hausner's ratio. Three of the GRT formulations were prepared using hydroxypropyl methylcellulose K4M (HPMC K4M) as a release-retarding polymer, at different concentrations. Results and Discussion: The mechanism of doxylamine released from the GRT formulations were then assessed by fitting the in vitro dissolution data obtained to zeroorder, first-order, Higuchi's, and Korsmeyer-Peppas models. It seems that formulations containing different concentrations of HPMCK4M, closely follow the first-order and Higuchi models for kinetic of drug release. Although the regression coefficients of zero-order and Korsmeyer-Peppas model for the three formulations showed relatively low values, all diffusion exponent (n) values, were above 0.5 value, which indicates that the mechanism of drug release from those formulations follow a non-Fickian release (diffusion and swelling) as expected from hydrophilic polymers like HPMC K4M. Conclusion: The use of a release-retarding polymer like HPMC K4M together with the floating-tablet technology can be applied to formulate basic drugs that have low solubility at the intestinal pH, to achieve sustained release pattern.

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Formulation and optimization of carbamazepine floating tablets

Abstract: New Antihistaminic Agents: Synthesis and Evaluation of H1-Antihistaminic actions of 3-[(N,N-Dialkylamino)alkyl)-1,2,3,4-tetrahydro-(1H)-thioquinazolin-4(3H)-ones and Their oxo Analogues

Cited by 22 publications

References 23 publications

Formulation and in Vitro Evaluation of Amlodipine Gastroretentive Floating Tablets Using a Combination of Hydrophilic and Hydrophobic Polymers

Formulation and in Vitro Evaluation of Amlodipine Gastroretentive Floating Tablets Using a Combination of Hydrophilic and Hydrophobic Polymers

Progress in Controlled Gastroretentive Delivery Systems

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